
Doctor Chantal Jm van Opbergen
Amsterdam University Medical Centre (AUMC), Amsterdam (Netherlands (The))
Biography
Dr. Chantal J.M. van Opbergen is a postdoctoral research fellow whose work centers on uncovering the molecular and cellular mechanisms underlying arrhythmogenic cardiomyopathy (ARVC) and mechanisms of cardiac arrhythmias in other inherited cardiomyopathies. She earned her PhD from Utrecht University (2020) by investigating calcium-sensitive pathways in ARVC, and subsequently continued her research at New York University School of Medicine (2019) and Amsterdam UMC (2023). Here, she focuses on multidisciplinary projects that bridge preclinical discovery with translational applications; including a gene therapy approach for PKP2-ARVC resulting in a Phase 1 FDA-approved clinical trial.
Contributor content
Presentation
Loss of nuclear envelope integrity and DNA damage in arrhythmogenic cardiomyopathy
Presentation
Leaky RyR2 channels as pro-arrhythmic trigger in the PKP2-deficient atrial myocardium
Presentation
Blockade of the adenosine 2A receptor mitigates the cardiomyopathy induced by loss of plakophilin-2 expression
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