CRISPR/Cas9-mediated correction of Troponin I R186Q mutation rescues myofibrillar disarray and excitation-contraction coupling abnormalities in IPSC model from hypertrophic cardiomyopathy patient
Event:
ESC Congress 2018
Topic:
Gene Therapy, Cell Therapy
Session:
Young Investigator Award Session Basic Science
Activation of the calcineurin-NFAT pathway in hypertrophic cardiomyopathy due to abnormal calcium homeostasis contributes to progression of cardiomyocytes hypertrophy: Insights from human iPSC model