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Doctor Oto Inoue

Cincinnati Children's Hospital Medical Center, Cincinnati (United States of America)

Member of:

European Society of Cardiology

Dr. Oto Inoue has years of experience with severe CVD patients as a physician and established skills including catheter intervention. His clinical experience has fueled his passion in therapeutic angiogenesis as an attractive strategy against severe CVD. Subsequently, he has dedicated himself to pursue the most effective graft for cell therapy. His representative skill sets include in vivo ischemic models and single-cell transcriptomics. Currently, he found that a subpopulation of adipose stromal/stem cells exhibited the most angiogenic gene profile using multiple scRNA-seq datasets from various human organs. His primary goal is to start clinical trials and develop novel cell therapies for ischemic disease. To proceed his research focusing on adipose/angiogenesis, he moved to the Cincinnati Children's in the U.S. from 2021 and is expanding skills in multiomics and lineage tracing at one of the renowned institutions participating in the Human Cell Atlas project.

Single-cell transcriptomics reveals an angiogenic cell population for therapeutic angiogenesis in adipose tissue

Event: ESC Congress 2022

Topic: Gene Therapy, Cell Therapy

Session: Young Investigator Awards Session in Basic Science

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Long-term engraftment of human CD271-positive adipose-derived stem cells with pericytic and less-aged gene profile in a mouse model of hindlimb ischemia

Event: ESC CONGRESS 2019

Topic: Gene Therapy, Cell Therapy

Session: Pharmacology, angiogenesis and cardiovascular disease

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Identification of the angiogenic subset of human adipose-derived stem cells by evaluation of capability to induce M2-dominant macrophage polarization in cell therapy

Event: ESC CONGRESS 2017

Topic: Stem cells and cell therapy

Session: Cardiac regeneration and repair

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Systemic insulin resistance and adipose tissue inflammation predict decreased therapeutic mesenchymal stem cells for autologous transplantation in patients with cardiovascular disease

Event: ESC CONGRESS 2016

Topic: Stem cells and cell therapy

Session: Cell and gene therapy

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