Cincinnati Children's Hospital Medical Center, Cincinnati (United States of America)
Member of:
Dr. Oto Inoue has years of experience with severe CVD patients as a physician and established skills including catheter intervention. His clinical experience has fueled his passion in therapeutic angiogenesis as an attractive strategy against severe CVD. Subsequently, he has dedicated himself to pursue the most effective graft for cell therapy. His representative skill sets include in vivo ischemic models and single-cell transcriptomics. Currently, he found that a subpopulation of adipose stromal/stem cells exhibited the most angiogenic gene profile using multiple scRNA-seq datasets from various human organs. His primary goal is to start clinical trials and develop novel cell therapies for ischemic disease. To proceed his research focusing on adipose/angiogenesis, he moved to the Cincinnati Children's in the U.S. from 2021 and is expanding skills in multiomics and lineage tracing at one of the renowned institutions participating in the Human Cell Atlas project.
Long-term engraftment of human CD271-positive adipose-derived stem cells with pericytic and less-aged gene profile in a mouse model of hindlimb ischemia
Event:
ESC Congress 2019
Topic:
Gene Therapy, Cell Therapy
Session:
Pharmacology, angiogenesis and cardiovascular disease
Identification of the angiogenic subset of human adipose-derived stem cells by evaluation of capability to induce M2-dominant macrophage polarization in cell therapy