Cardiovascular Research Institute Maastricht (CARIM), Maastricht (Netherlands (The))
Paul Volders, Cardiologist, Professor of Genetic Cardiology and Principal Investigator, coordinates the care of patients with inherited cardiomyopathies, including those with inherited arrhythmias, at Maastricht University Medical Center, The Netherlands. Within this clinical-experimental setting there is an active research program to gain novel insights in ventricular arrhythmias and sudden cardiac arrest. Traditionally, the Volders team has focused on the electrophysiological characterization of arrhythmia substrates in inherited cardiomyopathies and in acquired cardiac overload. Increasing research activities are directed to: (1) intracellular signaling pathways determining ion-channel function; (2) the genetic and genomic basis of cardiac arrhythmias; and (3) systems biology to integrate the basic molecular and functional determinants of arrhythmia syndromes with the clinical characteristics of individual patients.