Dr Hitoshi Matsuo is currently President of Gifu Heart Center, and Clinical Visiting Professor of Medicine in Aichi Medical University. He graduated from Jichi Medical School in 1986, and finished his residency in Gifu Prefectural Gifu Hospital. During the residency period, he spend one year at Johns Hopkins Medical Institutions in Baltimore as a research fellow of Nuclear Medicine Department from 1987 under the supervision of Professor Henry N Wagner Jr. From 1988. From 1988, he returned to Gifu Prefectural Hospital where he dedicated clinical research work on physiology and interventional cardiology using nuclear medicine and pressure wire. Dr Matsuo is now President of Gifu Heart Center, and a director of CVIT, JSCVI, JASNC and participating in and contributing to many international multi-center trials including DEFINE-FLAIR, DEFINE FLOW, international multicenter FFRCT registry (ADVANCE registry), 3V-FFR FRIENDS study and FAVOR2 Europe and Japan.