Graduated from the University Federico II of Naples in Medicine and Surgery in 1991 and specialized in Neurology at the Second University of Naples. His post-graduate experience continued in the laboratories of TIGEM in Milan with Professor Ballabio (1995-1996), in Naples at the Second University of Naples with Professor Nigro (1997-1998), at the Children's Hospital of Boston with Professor Kunkel (1998-2001) and became an Instructor in 2001 at Harvard Medical School. In 2001 he founded a biotechnology start-up, Centagenetix Inc. of which he was Vice President of Research until 2003. In 2001 he founded the Longevity Association incubated at the City of Science with which he recruits the Centenarians of Cilento. In 2006 he held the role of group leader at the IRCCS Multimedica. From 2020 is Full Professor of Medical Genetic (MED/03) at the University of Salerno where actually holds the position of of Director of Department of Medicine, Surgery and Dentistry of University of Salerno.