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Professor Hsiang-Chun Lee

Kaohsiung Medical University Hospital, Kaohsiung (Taiwan)

Member of:

European Society of Cardiology

Dr. Hsiang-Chun Lee’s current positions include Associate Professor, College of Medicine, Kaohsiung Medical University (KMU) and Attending Cardiologist, KMU Hospital. Dr. Lee started her PhD study of arrhythmias in 2008. During 2010 to 2013, she studied in Washington University in Saint Louis, where she incorporated the computational modeling and patch clamps to elucidate effects of alternative splicing of KCNQ1 on ventricular arrhythmogenicity (Heart Rhythm 2013). Dr. Lee created her Lab and initiated lipid researches in early 2014. She found that very-low-density lipoprotein (VLDL) of metabolic syndrome induces excess lipid accumulation and causes lipotoxicity, atrial cardiomyopathy with conduction delay (Scientific Reports 2017), calcium dysregulation and myofilament disarray (J Clin Med 2019) and ultimately vulnerability to atrial fibrillation (Int J Mol Sci 2016). She was the first to articulate the role of postprandial VLDL on atrial remodeling (Lipids Health Dis 2020).

VLDL induces EZH2/PRC2 complex-mediated cellular senescence in metabolic syndrome to enhance cardiotoxicity

Event: ESC Congress 2024

Topic: Genetics, Epigenetics, ncRNA

Session: Novel insights into ageing and senescence

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