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Relationship between polymorphism of ADRA2B gene and primary cardiac conduction disorders

Cardiac conduction system (CCS) disease resulting in disrupted conduction and impaired cardiac rhythm is common with significant morbidity and mortality. Current treatment options are limited and rational efforts to develop cell-based and regenerative therapies require knowledge in molecular networks that establish and maintain CCS function. Recent genome-wide association studies (GWAS) have identified numerous loci associated with adult human CCS function, including ADRA2B.  

A family examination was performed for 71 patients with atrioventricular block (AVB). The control group was formed by 657 patients without clinical ECG manifestations of cardiac diseases. All the examinees underwent ECG, echocardioscopy, electrophysiological examination of the heart. 

by results of research, it has been established that the frequency of carriers of a homozygous genotype on rare allele (DD) among patients with AVB (43.7%±5.9) was higher in comparison with the controls (16%±1.4). The obvious tendency to decrease in carriers of a heterozygous genotype (ID) among patients with AVB (23.9%±5.1) in comparison with the control group (51.1%±2.0) has also been noted. 

 In this work, we revealed association between hereditary disturbances of cardiac conduction and polymorphism of 2-adrenergic receptor gene using clinical - genetic material for the first time.