Open Access

FRAGILE: FRench Attitude reGistry in case of ICD LEad replacement

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Date: 30 November 2020
Journal: EP Europace Journal , Volume 23 , Issue 3 , Pages 389 - 394
Authors: C. Alonso , C. Marquie , P. Defaye , N. Clementy , P. Mondoly , N. Sadoul , S. Boveda , F. Hidden-Lucet , A. Dompnier , A. Da Costa , E. Marijon , C. Leclercq , G. Caudron , O. Piot , J. DEHARO

ESC Journals

AbstractAims

FRench Attitude reGistry in case of ICD LEad replacement (FRAGILE) registry was set-up to describe the attitude in different French institutions in case of implantable cardioverter-defibrillator (ICD) lead replacement, extraction, or abandonment and to compare outcomes in both groups.

Methods and results

Prospective observational study comparing two attitudes in case of ICD lead replacement, extraction, or abandonment. Primary endpoint describes the attitude in different French centres, collect parameters that may influence the decision. Secondary endpoint compares early and mid-term (2 years) complications in both groups.

Between April 2013 and April 2017, 552 patients were included in 32 centres. 434 (78.6%) were male, mean patient’s age was 60.3 ± 14.4 years. In 56.9% of the cases, the decision was to explant the lead. Patients in the extraction group were younger than in the abandonment group (56.7 ± 14.5 vs. 65 ± 12.7 P < 0.0001) and less likely to have comorbidities (46.5% vs. 58.3% of the patients P = 0.022). The mean lead dwelling time was significantly longer in the abandonment group as compared with the extraction group (7.6 ± 3.9 vs. 5.2 ± 3.1 years, P < 0.0001). There was no statistical difference between both groups concerning early and 2 years complications.

Conclusion

In this registry, the strategy in case of non-infected ICD lead replacement was mainly influenced by patient’s age and comorbidities and lead dwelling time. No difference was observed in outcomes in both strategies.

About the contributors

Christine Alonso

Role: Author

Christelle Marquie

Role: Author

Pascal Defaye

Role: Author