Open Access

Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia

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Date: 20 April 2021
Journal: EP Europace Journal , Volume 23 , Issue 9 , Pages 1350 - 1358
Authors: P. Taggart , E. Pueyo , S. Duijvenboden , B. Porter , M. Bishop , D. Sampedro-Puente , M. Orini , B. Hanson , C. Rinaldi , J. Gill , P. Lambiase

ESC Journals

Abstract

Strong recent clinical evidence links the presence of prominent oscillations of ventricular repolarization in the low-frequency range (0.04–0.15 Hz) to the incidence of ventricular arrhythmia and sudden death in post-MI patients and patients with ischaemic and non-ischaemic cardiomyopathy. It has been proposed that these oscillations reflect oscillations of ventricular action potential duration at the sympathetic nerve frequency. Here we review emerging evidence to support that contention and provide insight into possible underlying mechanisms for this association.

About the contributors

Peter Taggart

Role: Author

Esther Pueyo

Role: Author

Stefan van Duijvenboden

Role: Author