Open Access

Decreased glycolytic metabolism in non-compaction cardiomyopathy by <sup>18</sup>F-fluoro-2-deoxyglucose positron emission tomography: new insights into pathophysiological mechanisms and clinical implications

logo

Date: 30 March 2017
Journal: European Heart Journal - Cardiovascular Imaging , Volume 18 , Issue 8 , Pages 915 - 921
Authors: M. Tavares de Melo , M. Giorgi , A. Assuncao , R. Dantas , J. Araujo Filho , J. Parga Filho , A. Bierrenbach , C. de Lima , J. Soares , J. Meneguetti , C. Mady , L. Hajjar , R. Kalil Filho , E. Bocchi , V. Salemi

ESC Journals

AbstractAims

The pathophysiological mechanisms of left ventricular non-compaction cardiomyopathy (LVNC) remain controversial. This study performed combined 18F-fluoro-2-deoxyglucose dynamic positron emission tomography (FDG-PET) and 99mTc-sestamibi single-photon emission computed tomography (SPECT) studies to evaluate myocardial glucose metabolism and perfusion in patients with LVNC and their clinical implications.

Methods and results

Thirty patients (41 ± 12 years, 53% male) with LVNC, diagnosed by cardiovascular magnetic resonance (CMR) criteria, and eight age-matched healthy controls (42 ± 12 years, 50% male) were prospectively recruited to undergo FDG-PET with measurement of the myocardial glucose uptake rate (MGU) and SPECT to investigate perfusion-metabolism patterns. Patients with LVNC had lower global MGU compared with that in controls (36.9 ± 8.8 vs. 44.6 ± 5.4 μmol/min/100 g, respectively, P = 0.02). Of 17 LV segments, MGU levels were significantly reduced in 8, and also a reduction was observed when compacted segments from LVNC were compared with the segments from control subjects (P < 0.001). Perfusion defects were also found in 15 (50%) patients (45 LV segments: 64.4% match, and 35.6% mismatch perfusion-metabolism pattern). Univariate and multivariate analyses showed that beta-blocker therapy was associated with increased MGU (beta coefficient = 10.1, P = 0.008). Moreover, a gradual increase occurred in MGU across the beta-blocker dose groups (P for trend = 0.01).

Conclusion

The reduction of MGU documented by FDG-PET in LVNC supports the hypothesis that a cellular metabolic pathway may play a role in the pathophysiology of LVNC. The beneficial effect of beta-blocker mediating myocardial metabolism in the clinical course of LVNC requires further investigation.

About the contributors

Marcelo Dantas Tavares de Melo

Role: Author

Maria Clementina Pinto Giorgi

Role: Author

Antonildes Nascimento Assuncao

Role: Author