Purpose: The aim of this study was to investigate the prevalence of CMD in type 2 diabetic patients
with normal rest-stress myocardial perfusion imaging using CZT-Spect.
Methods: 40 type 2 diabetic patients without history of cardiovascular disease were referred for gated spect perfusion dipyridamole rest-stress test and CFR assessment with DSpect® using Tc-99m MIBI. Normal perfusion images were defined visually by consensus of two experimented nuclear cardiologists and compared with normal database. CFR was obtained by stress / rest flow ratio with 4DM® software. CMD was defined as CFR < 2. Relationships between CFR and glycated haemoglobin, LDL-cholesterol and systolic blood pressure were determined.
Results: Median CFR in diabetic patients was lower than healthy controls (1.86 vs 2.58; p<0,001). The prevalence of CMD in diabetics was 53% with gender differences between groups (table). No significant correlations between CFR, glycated haemoglobin, LDL-cholesterol or systolic blood pressure were found.
Conclusion: We found a high prevalence of CMD in type 2 diabetic patients with normal rest-stress perfusion study. Females are more affected than men.