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Early post-stress decrease in cardiac peformance by impedance cardiography and its relation to the severity and extent of ischemia by myocardial perfusion imaging
R Goldkorn1
,
A Naimushin1
,
E Rozen1
,
D Freimark1
,
1Chaim Sheba Medical Center - Tel Hashomer - Israel
,
Citation:
Background: Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is a well-established noninvasive procedure for the evaluation and risk stratification of patients with coronary artery disease (CAD); however, in certain patients it is unable to detect the presence of or underestimates the extent of CAD. The Non-Invasive Cardiac System (NICaS, NI Medical, Israel) is a whole-body bio-impedance device capable of measuring various hemodynamic parameters. Noninvasive detection of an early post-stress decrease in cardiac performance may serve as a potential marker for the presence of significant or extensive ischemia.
Purpose: We aimed to test for an early post-stress change in several hemodynamic parameters by impedance cardiography and its relation to the severity and extent of myocardial ischemia in patients undergoing exercise stress MPI.
Methods: We prospectively enrolled patients who were referred to the Nuclear Cardiology Center at the Sheba Medical Center for a clinically indicated exercise stress MPI study. All patients underwent testing using the NICaS before exercise and immediately after exercise. The differences between rest and stress hemodynamic parameters were compared with the severity and extent of myocardial ischemia by MPI.
Results: The study population included 198 patients; mean age was 62 years, 26% were women, 54% had hypertension, and 29% diabetes mellitus. 188 patients had =10% of ischemic myocardium and 10 patients had >10% of ischemic myocardium. In the first group, compared to rest, there was a significantly greater increase in post-exercise stroke index, stroke work index, cardiac index and cardiac power index (19.2%, 29.1%, 90.5% and 107%, respectively) when compared to the second group (-2.7%, 3.8%, 43.7% and 53.5%, respectively) as well as a significantly greater decrease in total peripheral resistance index (-38.7%) when compared to the second group (-16.3%), with corresponding p values of 0.015, 0.017, 0.040, 0.016, and <0.001, respectively.
Conclusions: Our data suggest that the immediate post-stress changes in several hemodynamic parameters as detected by the NIcAS can be used as an important adjunct to SPECT MPI for the early detection of myocardial ischemia.
ESC 365 is supported by Bayer, Boehringer Ingelheim and Lilly Alliance, Bristol-Myers Squibb and Pfizer Alliance, Novartis Pharma AG and Vifor Pharma in the form of educational grants. The sponsors were not involved in the development of this platform and had no influence on its content.
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