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Technical and economical evaluation for feasibility for implementing small cyclotron systems in Europe for cardiac pet with the tracer 13N-NH3

Session Poster session I

Speaker Klaas Pieter Koopmans

Congress : ICNC, Nuclear Cardiology & Cardiac CT 2019

  • Topic : imaging
  • Sub-topic : Positron Emission Tomography (PET)
  • Session type : Poster Session
  • FP Number : P150

Authors : K Koopmans (Groningen,NL), GS Pronk (Groningen,NL), A Talsma (Groningen,NL), JR Moes (Groningen,NL), RHJ Slart (Groningen,NL), SV Lazarenko (Alkmaar,NL)


K Koopmans1 , GS Pronk1 , A Talsma2 , JR Moes2 , RHJ Slart3 , SV Lazarenko4 , 1Martini Hospital , Department of radiology and nuclear medicine - Groningen - Netherlands (The) , 2Martini Hospital, department of medical physics - Groningen - Netherlands (The) , 3University Medical Center Groningen, Department of nuclear medicine - Groningen - Netherlands (The) , 4Medical Center Alkmaar, Department of nuclear medicine - Alkmaar - Netherlands (The) ,



Cardiac PET is superior to myocardial perfusion SPECT for the detection of cardiac ischemia. Hight costs of cardiac PET tracers have restricted propagation of this method.


To evaluate the technical and economical feasibility of 13N-NH3 cardioPET with a  dedicated cyclotron on a large scale.


A questionnaire was send to cyclotron manufacturers. IBA and GE were able to provide data and costs of available complete systems. Based on their data, we calculated whether the production of 13N-NH3 would be enough for our scanning protocol including loss through processing and dispensing (300 MBq for 12 min rest, 3 min wait, and 400 MBq for 10 min stress within one session).

We calculated costs per scan for 1500 patients, and included cost for tracer, camera systems, alteration of the building, maintenance and depreciation of scanners 10 years and cyclotron (20 years).


Although different preparation schedules are required, both cyclotron systems produce enough 13N-NH3 for our scanning protocol.

Costs were calculated to be €397 for MPI SPECT, €447 for cardiac PET


13N-NH3 cardiac PET is an economically affordable superior alternative to MPI SPECT, when using dedicated cyclotron systems.

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