In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.


This content is currently on FREE ACCESS

 

Low-dose comprehensive cardiac CT for quantitative assessment of coronary artery disease: evaluation in a swine animal model

Session Moderated Posters 2

Speaker Sabee Molloi

Congress : ICNC, Nuclear Cardiology & Cardiac CT 2019

  • Topic : imaging
  • Sub-topic : CT Myocardial Perfusion
  • Session type : Moderated Posters
  • FP Number : 86

Authors : S Molloi (Irvine,US), L Hubbard (Irvine,US), S Malkasian (Irvine,US), Y Zhao (Irvine,US), P Abbona (Irvine,US)

15 views

Authors:
S Molloi1 , L Hubbard1 , S Malkasian1 , Y Zhao1 , P Abbona1 , 1University of California at Irvine - Irvine - United States of America ,

Citation:

Purpose: To evaluate a low-dose comprehensive cardiac CT technique for combined morphological and physiological assessment of coronary artery disease.

Materials and Methods: The low-dose comprehensive cardiac CT technique, which consists of whole-organ CT blood flow, CT angiography, and coronary flow reserve (CFR), was evaluated in twelve swine (43 ± 11 kg) under rest and stress conditions by direct comparison to a previously validated whole-organ CT blood flow technique. In three of the swine, intermediate stenoses with fractional flow reserve severities of 0.70 - 0.90 were also assessed. Contrast and saline were injected peripherally (370 mgI/mL contrast: 1 mL/kg at 5 mL/s; saline: 0.5 mL/kg at 5 mL/s) followed by dynamic volume scan acquisition with a 320-slice CT scanner. For each flow condition, only two volume scans were acquired for the low-dose comprehensive cardiac CT technique, while 20 volume scans were acquired for the reference standard retrospective technique. All of the comprehensive cardiac CT flow measurements were then compared to corresponding reference standard flow measurements through regression analysis. The  and size-specific dose estimate of the comprehensive cardiac CT technique were also computed and used to estimate effective dose.

Results: Low-dose comprehensive cardiac CT flow measurements (FLOW) were in good agreement with reference standard flow measurements (FREF) (FLOW = 1.04 FREF - 0.08, r = 0.94, RMSE = 0.32 mL/min/g). The  of rest flow, stress flow, CFR, rest flow combined with CT angiography, and CFR combined with CT angiography were 2.30, 2.30, 4.60, 5.75, and 8.05 mGy, respectively, with corresponding size-specific dose estimates of 3.66, 3.66, 7.31, 9.14, and 12.80 mGy. In combination, the maximum effective dose and size-specific effective dose of the comprehensive cardiac CT technique were 1.8 and 2.87 mSv, respectively.

Conclusion: Accurate morphological and physiological assessment of coronary artery disease is feasible with a low-dose comprehensive cardiac CT technique based on a whole-organ CT blood flow measurement technique.



Based on your interests

Three reasons why you should become a member

Become a member now
  • 1Access your congress resources all year-round on the New ESC 365
  • 2Get a discount on your next congress registration
  • 3Continue your professional development with free access to educational tools
Become a member now

Our sponsors

ESC 365 is supported by Bayer, Boehringer Ingelheim, Bristol-Myers Squibb and Pfizer Alliance, and Novartis Pharma AG. The sponsors were not involved in the development of this platform and had no influence on its content.

logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are