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Cross talk between endothelial dysfunction and myocardial fibrosis in patients with heart failure: the role of galectin-3.

Session Poster Session 4

Speaker Evangelos Oikonomou

Event : Heart Failure 2019

  • Topic : heart failure
  • Sub-topic : Chronic Heart Failure: Peripheral Circulation, Metabolism, Skeletal Muscle
  • Session type : Poster Session

Authors : E Oikonomou (Athens,GR), D Karlis (Athens,GR), S Tsalamandris (Athens,GR), G Siasos (Athens,GR), C Chrysohoou (Athens,GR), G Vogiatzi (Athens,GR), VC Mystakidi (Athens,GR), G Marinos (Athens,GR), D Tousoulis (Athens,GR)

Authors:
E Oikonomou1 , D Karlis1 , S Tsalamandris1 , G Siasos1 , C Chrysohoou1 , G Vogiatzi1 , VC Mystakidi1 , G Marinos1 , D Tousoulis1 , 1Hippokration Hospital, University of Athens, 1st Department of Cardiology - Athens - Greece ,

Citation:

Background: Endothelial function is impaired in patients with heart failure (HF) and may contribute to clinical status of HF patients. Galectin-3 is a mediator of myocardial fibrosis and remodeling, and is related to prognosis patients.

Purpose: To examine the association of endothelial dysfunction with galectin-3 levels in patients with HF of ischemic etiology. 

Methods: We consecutive enrolled 82 subjects with stable ischemic HF and reduced ejection fraction. Ultrasonographic recordings of the brachial artery were used to assed non-invasively endothelial function by means of flow mediated dilation (FMD). Among other factors serum levels of galectin-3 and b-type natriuretic peptide (BNP) were measured in blood samples. 

Results: The median values of galectin-3 in our study population was 14. (11.2-19.9) ng/ml and the mean value of FMD in our study population was 5.90±2.99%. There was significant association of Galectin-3 levels with age (r=0.35, p<0.001) with creatine clearance (r=-0.50, p<0.001) and with BNP levels (r=0.29, p=0.003). Importantly there was a significant inverse association of Galectin-3 levels with FMD (r=-0.21, p=0.04) (Figure).

Conclusions: In the present study we found that there is association of endothelial dysfunction with galectin-3 levels in patients with chronic HF of ischemic etiology implying the central role of endothelial ysfunction in the development and progression of ischemic heart failure.

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