Methods: Brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, and flow-mediated vasodilatation in brachial artery (FMD), a marker of endothelial function, were obtained in 674 patients with CAD at the baseline of FMD-J study.
Results: Among these patients, left ventricular ejection fraction (LVEF) <50% was observed in 83 patients. While FMD (4.3±2.6 % vs. 4.7±2..8 %, p=0.19) was similar, baPWV (15.5±2.4 m/s vs. 16.4±2.9 m/s, p<0.05) was lower, and diameter of brachial artery was larger (4.5±0.7 mm vs. 4.3±0.6 mm, p<0.05) in patients with LVEF <50% (n=83) than in those with LVEF >50% (n=591). Multivariate analysis, adjusted with age, smoking status, blood pressure, and medication for hypertension, demonstrated that LVEF was a significant determinant for brachial-arterial diameter but not baPWV.
Conclusion: In patients with CAD, reduced cardiac systolic function may be associated with vascular morphological abnormality rather than functional abnormalities.