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The association of reduced cardiac systolic function with morphological vascular abnormality rather than functional vascular abnormality in coronary artery disease

Session Poster Session 4

Speaker Hirofumi Tomiyama

Congress : Heart Failure 2019

  • Topic : heart failure
  • Sub-topic : Chronic Heart Failure: Peripheral Circulation, Metabolism, Skeletal Muscle
  • Session type : Poster Session
  • FP Number : P2075

Authors : HT Tomiyama (Tokyo,JP), TC Chikamori (Tokyo,JP), AY Yamashina (Tokyo,JP)

HT Tomiyama1 , TC Chikamori1 , AY Yamashina1 , 1Tokyo Medical University - Tokyo - Japan ,

On behalf: FMDJ study


Aims: FMD-J study is a multicenter prospective observational study to examine the usefulness of vascular function (endothelial function and arterial stiffness) in clinical management in patients with coronary artery disease (CAD). The present cross-sectional study, as a sub-analysis of FMD-J study, was conducted to examine whether reduced cardiac systolic function is differently associated with the vascular functional or morphological abnormalities in patients with CAD.

Methods: Brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, and flow-mediated vasodilatation in brachial artery (FMD), a marker of endothelial function, were obtained in 674 patients with CAD at the baseline of FMD-J study.

Results: Among these patients, left ventricular ejection fraction (LVEF) <50% was observed in 83 patients. While FMD (4.3±2.6 % vs. 4.7±2..8 %, p=0.19) was similar, baPWV (15.5±2.4 m/s vs. 16.4±2.9 m/s, p<0.05) was lower, and diameter of brachial artery was larger (4.5±0.7 mm vs. 4.3±0.6 mm, p<0.05) in patients with LVEF <50% (n=83) than in those with LVEF >50% (n=591). Multivariate analysis, adjusted with age, smoking status, blood pressure, and medication for hypertension, demonstrated that LVEF was a significant determinant for brachial-arterial diameter but not baPWV.

Conclusion: In patients with CAD, reduced cardiac systolic function may be associated with vascular morphological abnormality rather than functional abnormalities.

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