Hemodynamic of pulmonary arterial hypertension (PAH) has been poorly characterized in Latin America.
The aim of this report was to compare the hemodynamic and clinical profile among subgroups of PAH in Argentina.
Method: From Jul-14 to Oct-16, 399 incident and prevalent patients with PAH were prospectively included by 72 investigators from 23 provinces of Argentina in a collaborative registry. Patients must fulfill all the following inclusion criteria: 1-Age over three months; 2 - mean pulmonary arterial pressure (mPAP) at rest = 25 mmHg by right heart catheterization (RHC) and 3 - clinical stability in the absence of hospitalization in last month. The subgroups of PAH were defined as idiopathic, heritable or drugs associated (1), associated with connective tissue disease (2), HIV (3), porto-pulmonary hypertension (4), and congenital heart disease (5).
Results: The proportion of patients in subgroups 1 to 5 was: 1=41.9%, 2=23.8%, 3=5%, 4=4% and 5: 25.3%. The full comparison of clinical characteristics and hemodynamics parameter is shown in Table. Conclusion: In concordance with other international surveys, this Latin American registry showed that despite differences in hemodynamic profile among subgroups in PAH the clinical presentation was similar.
These findings suggest that different factors besides hemodynamic may have influence in the severity of the disease.