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Diagnostic value of NT proBNP in patients with myocarditis and preserved left ventricular systolic function

Session Poster Session 3

Speaker Borges Sara

Congress : Heart Failure 2019

  • Topic : valvular, myocardial, pericardial, pulmonary, congenital heart disease
  • Sub-topic : Myocarditis
  • Session type : Poster Session
  • FP Number : P1813

Authors : S Borges (Vila Real,PT), F Goncalves (Vila Real,PT), JP Guimaraes (Vila Real,PT), JJ Monteiro (Vila Real,PT), C Ferreira (Vila Real,PT), JI Moreira (Vila Real,PT)

S Borges1 , F Goncalves1 , JP Guimaraes1 , JJ Monteiro1 , C Ferreira1 , JI Moreira1 , 1Hospital Center of Tras-os-Montes and Alto Douro, Cardiology - Vila Real - Portugal ,


Background: The diagnostic role of N-terminal pro B-type natriuretic peptide (NT- proBNP) in patients with heart failure and left ventricular (LV) dysfunction has been extensively studied. Nevertheless, upper normal NT-proBNP levels can be found in many circumstances without decreased LV ejection fraction (LVEF). The purpose of this study is to evaluate the diagnostic value of BNP in patients with myocarditis and preserved LVEF

Methods: We retrospectively analysed data from patients (pts) admitted in one center, with the diagnosis of myocarditis, from 2008 and 2018;

Results: 63 patients were included. Mean age was 38.8 +/- 16 years and 91% (53) were men. Out of those, 58 (94%) had preserved LVEF (mean 59.9 +/- 4.27%) Average length of stay in hospital was 5 days;

The NT-proBNP values ranged from 24 to 3110 pg/mL (median 482 ng/mL; interquartile range (IQR) = 768). Regarding the group of pts with preserved LVEF, 80% (44pts) had plasma levels of NT-proBNP > 120 ng/mL [upper reference limit]; NT-proBNP positively correlated with peak troponin (p= 0.006, r= 0, 37), leucocyte (p= 0.05, r= 0.25) and neutrophil to lymphocyte ratio (p= 0.003, r= 0.26).

Conclusion: In this population, the majority of the patients with myocarditis did not have significant LV systolic dysfunction, as measured by LVEF; Despite that, most of them presented high levels of BNP at admission. In this subset of patients, in which clinical presentation is highly variable, NT-proBNP measurement may be an important adjuvant in early assessment of myocarditis, regardless LVEF;

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