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VEGF-A gene polymorphism and VEGF-A level association with the development of heart failure in patients with ST-elevation myocardial infarction

Session Poster Session 3

Speaker Iulia Rodionova

Event : Heart Failure 2019

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Coronary Artery Disease: Treatment, Revascularization
  • Session type : Poster Session

Authors : I Rodionova (Kharkiv,UA), I N Kutya (Kharkiv,UA), MP Kopytsya (Kharkiv,UA), YJ Samburg (Kharkiv,UA), NV Tytarenko (Kharkiv,UA), BA Shelest (Kharkiv,UA)

Authors:
I Rodionova1 , I N Kutya1 , MP Kopytsya1 , YJ Samburg2 , NV Tytarenko1 , BA Shelest3 , 1L.T.Malaya Institute of Therapy - Kharkiv - Ukraine , 2Kharkiv National Academy of Postgraduate Education - Kharkiv - Ukraine , 3Kharkiv National Medical University - Kharkiv - Ukraine ,

Citation:

The purpose of the study was to assess the predictive value of Vascular endothelial growth factor A (VEGF-A) in associated with in cardiac remodeling and  exercise capacity of the VEGF-A gene polymorphism (rs 2010963) with the development of heart failure in patients with ST-Elevation Myocardial Infarction (STEMI) in a 6-month period.

Materials and methods: 91 patients with acute STEMI were examined, 70 (76.9%) males, mean age - 59.21 ± 8.92. The level of the VEGF-A  determined by ELISA. VEGF-A gene polymorphism (rs 2010963)  assessed by polymerase chain reaction. All patients  tested with a 6-minute walking test (6MWT).

Results. Carriers of the genotype GG have a significantly higher level of VEGF-A - 194.10 [115.02-398.86] pg / ml compared to the GC genotype with 148.44 [68.84-221.28] pg / ml, (P = 0.047). The frequency of STEMI was 2.58 times higher in the GC genotype. The 6MWT was 477.35 ± 73.34 m in the GC type, meanwhile, the GG genotype resulted in 545.44 ± 51.09 m (P = 0.014). The ROC analysis determined the cut-off level of VEGF-A = 199.5 pg / ml, as a predictor for left ventricle (LV) remodelling and for poor exercise capacity with a sensitivity of 77.4% and a specificity of 63.3% (AUC 0.654, 95% CI 0.513-0.795, p = 0.032).

Conclusions: The GC genotype in patients with STEMI is associated with more pronounced changes in the LV geometry and poor exercise capacity. The VEGF-A can be suggested as possible predictor for heart failure development in STEMI patients.

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