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Benefits of early administration of ivabradine in stabilized patients hospitalized due to worsening heart failure: insights from the Optimize Heart Failure Care Program

Session Poster Session 3

Speaker Lilyana Mircheva

Event : Heart Failure 2019

  • Topic : heart failure
  • Sub-topic : Chronic Heart Failure: Pharmacotherapy
  • Session type : Poster Session

Authors : LG Mircheva (Varna,BG), Y T Yotov (Varna,BG)

LG Mircheva1 , Y T Yotov1 , 1Medical University - Varna - Bulgaria ,

On behalf: Optimize Heart Failure Care Program


Heart failure (HF) affects quality of life (QoL). High heart rate (HR) is an important prognostic factor and worsens further the QoL in patients with HF.

Aim: to assess the benefits of early administration of Ivabradine (Iv) on QoL in patients with HF.

Subjects and methods: Overall, 156 patients at a mean age 68 years, 69% males, were actively followed for 6 months. All patients were evaluated for their demographic data and etiology and by echocardiography at baseline before dehospitalization from the Clinic and lab tests including NTproBNP, quality of life measures, 6-minute walking test (6MWT), NYHA class, and clinical examination at follow-up visits were done.

Results: Iv was administered in 18.4% of all patients, 27% of the patients in sinus rhythm. The administration of Iv improved all measures of QoL (Table1). The distance covered at 6MWT increased more with 53.9 m in Iv group.

Conclusions: The early administration of HR reducing therapy including Iv improve the QoL in all dimensions.

Ivabradine + Ivabradine - P
EF % +3.4 -0.89 NS


after 6 mo

77 44 0.023
KCCQ units +21.65 +15.7 NS
VAS % +15 +12 NS
EQ5 units +0.13 +0.14 NS

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