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Sacubitril valsartan, a multicentric experience

Session Poster Session 3

Speaker Francisco Javier Cortes

Event : Heart Failure 2019

  • Topic : heart failure
  • Sub-topic : Chronic Heart Failure: Pharmacotherapy
  • Session type : Poster Session

Authors : FJ Cortes (Seville,ES), DF Arroyo Monino (Seville,ES), MI Fernandez Valenzuela (Seville,ES), MI Rivadeneira Ruiz (Seville,ES), P Ruiz Garcia (Seville,ES), M Chaparro Munoz (Seville,ES), AJ Castro Fernandez (Seville,ES), A Recio Mayoral (Seville,ES)

FJ Cortes1 , DF Arroyo Monino1 , MI Fernandez Valenzuela1 , MI Rivadeneira Ruiz1 , P Ruiz Garcia1 , M Chaparro Munoz1 , AJ Castro Fernandez1 , A Recio Mayoral1 , 1Virgen Macarena University Hospital - Seville - Spain ,


Introduction: In the years following the publication of PARADIGM-HF trial in 2014, a growing evidence supports the safety and efficacy of sacubitril/valsartan in patients with HFrEF. The purpose of this study is to analyse the impact of sacubitril/valsartan on real world heart failure cohort.

Material and methods: We performed a prospective observational study with patients with HFrEF pick out in outpatient clinic, who started treatment with Sacubitril/Valsartan between January 2016-January 2018. We analysed their baseline characteristics and the functional class, renal function and drug tolerance in one year follow-up.

Results: 336 patients were included during the observed time period, with a mean age of 67,55 ± 10,93 years, being 24,5% female. The main basaline ejection fraction was 30,1 ± 6,8. The main cause of heart failure was ischemic heart disease (42,7%). Initially, the majority were in FC II-III (87%). In a review at 12 months follow-up, ARNI was at low doses in 23%, at medium doses 32% and the rest at high doses. Only a small proportion of patients (11%) have been down-titrated after achieving the maximal target dose of sacubitril/valsartan by sintomatic hipotension. Concerning analytical parameters, we did not find significant differences in renal function or in potassium levels during follow-up.

Conclusions: The treatment with sacubitril/valsartan in a group of patients in real-life was generally well tolerated with a significant decrease in blood pressure, being able to optimize the dose of sacubitril/valsartan. It was also related to improvement in the functional class without find significant differences in renal function during follow-up.

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