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Evaluation of the effectiveness of lisinicore and losartan in patients with chronic heart failure

Session Poster Session 3

Speaker Umida Kamilova

Event : Heart Failure 2019

  • Topic : heart failure
  • Sub-topic : Chronic Heart Failure: Comorbidities
  • Session type : Poster Session

Authors : U Kamilova (Tashkent,UZ), Z Rasulova (Tashkent,UZ), D Masharipova (Tashkent,UZ), G Zakirova (Tashkent,UZ)

U Kamilova1 , Z Rasulova1 , D Masharipova1 , G Zakirova2 , 1Republican specialized scientific-practical Medical Center Therapy and Medical Rehabilitation - Tashkent - Uzbekistan , 2Tashkent medical academy - Tashkent - Uzbekistan ,


Purpose. To study the effect of lisinopril and losartan on the functional state of the kidneys of patients with I-III functional class (FC) of chronic heart failure (CHF), depending on the degree of renal dysfunction (RD).

Methods. A total of 223 patients with ischemic heart disease with I-III FC of CHF were examined, initially and after 6 months of treatment. The first group (I) consisted of 118 patients taking lisinopril as part of standard therapy; the second group (II) - 105 patients taking losartan. Also, all patients were divided into 2 groups depending on the estimated glomerular filtration rate (eGFR): 30 60 ml / min / 1,73m2 -156 patients (89 patients in group 1,67 patients in group 2).

Results. The nephroprotective effect of standard therapy with the inclusion of lisinopril or losartan was noted, with a significant decrease in the level of enzymes in the urine, as a sign of dysfunction of the tubular kidney apparatus, a decrease in creatinine, and an increase in GFR. In patients with CHF with a preserved eGFR> 60 ml / min / 1,73 m2 and moderate RD with eGFR = 59-45 ml / min / 1,73 m2, the use of standard lisinopril or losartan showed reliable nephroprotection. In patients with CHF with kidney dysfunction with 30> eGFR <45 ml / min / 1,73 m2, a significant improvement in renal dysfunction was observed in the group of patients taking standard therapy - losartan.

Conclusion. The results of our studies in patients with CHF showed that RD appeared at the subclinical stage, when the majority of patients do not have clinical signs of renal failure, which is also correlated with the findings of other researchers. According to many studies, the positive effect of ACE I and ARA is due to the fact that they reduce the initially high blood pressure in glomeruli of the kidneys, which stops the development of glomerulosclerosis

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