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Early effects of Sacubitril/valsartan on exercise tolerance in patients with heart failure with reduced ejection fraction.

Session Poster Session 2

Speaker Giuseppe Vitale

Event : Heart Failure 2019

  • Topic : heart failure
  • Sub-topic : Treatment
  • Session type : Poster Session

Authors : G Vitale (Palermo,IT), S Sarullo (Palermo,IT), C Nugara (Palermo,IT), F M Sarullo (Palermo,IT)

G Vitale1 , S Sarullo2 , C Nugara1 , F M Sarullo1 , 1Buccheri La Ferla Fatebenefratelli Hospital - Palermo - Italy , 2University of Palermo - Palermo - Italy ,

Chronic Heart Failure – Treatment

Introduction. Sacubitril/valsartan in patients with heart failure (HF) with reduced ejection fraction (HFrEF) was shown to be superior to enalapril in reducing the risk of death and hospitalization for HF.

Purpose. Our aim was to evaluate the cardiopulmonary effect of sacubitril/valsartan HFrEF patients.

Methods. In this observational study 94 patients with HFrEF underwent serial cardiopulmonary tests (CPET)  after initiation of sacubitril/valsartan in addition to recommended therapy.

Results. At baseline, 38% of patients had New York Heart Association (NYHA) class III HF, mean left ventricular ejection fraction (LVEF) was 27 ± 6%. After a mean follow-up of 7.4 ± 3.6 months systolic blood pressure decreased from 117±14 mm Hg to 101±12 mm Hg (p< .0001); Peak oxygen consumption (VO2) improved from 14.7±3.3 mL/kg/min at baseline (% of predicted = 54.2±14)  to 17.3±4.7 mL/kg/min after follow-up (% of predicted = 65.3±17.6) (p< .001), oxygen pulse increased from 11.6±2.9 at baseline to 13.7±4.2 mL/kg/min at follow-up (p< .001). VE/VCO2 Slope decreased from 34±6.3 to 31.9±6 (p= .024).

Conclusion. In ambulatory patients with HFrEF, administration of sacubitril/valsartan improved exercise tolerance, peak oxygen consumption and ventilatory efficiency at 7.4 ± 3.6  months follow-up. Further studies are necessary to better clarify underlying mechanisms of this functional improvement.

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