In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.

The free consultation period for this content is over.

It is now only available year-round to HFA Silver & Gold Members, Fellows of the ESC and Young combined Members

Prognostic value of depression, anxiety disorders and inflammatory markers in patients with heart failure

Session Poster Session 1

Speaker Associate Professor Emine Gazi

Event : Heart Failure 2019

  • Topic : heart failure
  • Sub-topic : Chronic Heart Failure – Epidemiology, Prognosis, Outcome
  • Session type : Poster Session

Authors : E Gazi (Canakkale,TR), E Karaahmet (Istanbul,TR), H Turkon (Canakkale,TR), A Barutcu (Canakkale,TR)

Authors:
E Gazi1 , E Karaahmet2 , H Turkon3 , A Barutcu1 , 1Canakkale Onsekiz Mart University, Faculty of Medicine, Department of Cardiology - Canakkale - Turkey , 2Okmeydani Training and Research Hospital, Psychiatry - Istanbul - Turkey , 3Canakkale 18 March University, Biochemistery - Canakkale - Turkey ,

Citation:

Background: Heart failure (HF) is a public health problem. Depression and anxiety are more common in HF patients than normal population.
Purpose: We aimed in this study to investigate the relation between depression and inflammatory parameters on survival and hospitalization in HF patients.

Methods: A total of 122 consecutive patients with ejection fraction (EF) =45% were included in this prospective study. N-terminal brain natriuretic peptide (NT-proBP), high sensitive C-reactive protein (hs-CRP), tumor necrosis factor alfa (TNF-a), interleukin 6 (IL-6) and neutrophile to lymphocyte ratio (NLR) were evaluated for inflammatory system.

Results: Mean follow-up was 36,4 months. Non-survivors are older  (68,6±9,7 vs. 61 ± 8,8 years, p<0,001), have lower EF (32,5 ±6,4% vs. 35,1±6,5%, p=0,037), decreased GFR (51,3 ±19,5 vs. 65,6 ±19,3 ml/min, p<0,001) and serum sodium level (135 ±19 vs. 139 ± 2, p=0,04) (Table 1).  Kaplan–Meier survival curves are shown Figure 1.

Conclusions: Depression, anxiety and inflammatory markers were not related to mortality in heart failure patients. Age, EF and GFR was found as independent predictors of mortality.

Univariate

Multivariate

Variable

HR

CI 95%

p

HR

CI 95%

p

Age (years)

1.08

1,04-1,12

<0,001

1,08

1,04-1,14

<0,001

EF

0,94

0,9- 0,98

0,015

0,93

0,89-0,98

0,014

GFR

0,96

0,95-0,98

<0,001

0,97

0,95-0,99

0,028

Sodium

0,98

0,96-0,99

0,036

NLR

1,31

1,12-1,52

<0,001

hsCRP

1,01

0,99-1,04

0,216

TNFα

1,00

0,99-1,01

0,789

IL-6

1,00

0,99-1,00

0,870

NT-proBNP

1,00

1,00-1.00

0,970

SF pain

0,95

0,92-0,98

0,006

SF general health

0,96

0,93-0,99

0,037

MCS

1,01

0,981,05

0,322

PCS

0,98

0,96-1,01

0,240

NYHA class

2,77

1,63-4,7

<0,001

HAM-A

1,0

0,97-1,03

0,622

HAM-D

1,00

0,97-1,03

0,819

Cox regression analysis for cardiovascular mortality

Members get more

Join now
  • 1ESC Professional Members – access all resources from general ESC events 
  • 2ESC Association Members (Ivory, Silver, Gold) – access your Association’s resources
  • 3Under 40 or in training - with a Combined Membership, access all resources
Join now

Our sponsors

ESC 365 is supported by Bayer, Boehringer Ingelheim and Lilly Alliance, Bristol-Myers Squibb and Pfizer Alliance, Novartis Pharma AG and Vifor Pharma in the form of educational grants. The sponsors were not involved in the development of this platform and had no influence on its content.

logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are