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Prognostic value of depression, anxiety disorders and inflammatory markers in patients with heart failure
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1Canakkale Onsekiz Mart University, Faculty of Medicine, Department of Cardiology - Canakkale - Turkey
2Okmeydani Training and Research Hospital, Psychiatry - Istanbul - Turkey
3Canakkale 18 March University, Biochemistery - Canakkale - Turkey
Background: Heart failure (HF) is a public health problem. Depression and anxiety are more common in HF patients than normal population. Purpose: We aimed in this study to investigate the relation between depression and inflammatory parameters on survival and hospitalization in HF patients.
Methods: A total of 122 consecutive patients with ejection fraction (EF) =45% were included in this prospective study. N-terminal brain natriuretic peptide (NT-proBP), high sensitive C-reactive protein (hs-CRP), tumor necrosis factor alfa (TNF-a), interleukin 6 (IL-6) and neutrophile to lymphocyte ratio (NLR) were evaluated for inflammatory system.
Results: Mean follow-up was 36,4 months. Non-survivors are older (68,6±9,7 vs. 61 ± 8,8 years, p<0,001), have lower EF (32,5 ±6,4% vs. 35,1±6,5%, p=0,037), decreased GFR (51,3 ±19,5 vs. 65,6 ±19,3 ml/min, p<0,001) and serum sodium level (135 ±19 vs. 139 ± 2, p=0,04) (Table 1). Kaplan–Meier survival curves are shown Figure 1.
Conclusions: Depression, anxiety and inflammatory markers were not related to mortality in heart failure patients. Age, EF and GFR was found as independent predictors of mortality.
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Cox regression analysis for cardiovascular mortality
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