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Predictors of combined critical endpoint (all-cause death/heart failure hospitalization) in patients with chronic heart failure and reduced left ventricular ejection fraction.

Session Poster Session 1

Speaker Alina Lyashenko

Event : Heart Failure 2019

  • Topic : heart failure
  • Sub-topic : Chronic Heart Failure – Epidemiology, Prognosis, Outcome
  • Session type : Poster Session

Authors : A Lyashenko (Kiev,UA), P Babich (Kiev,UA), N Tkach (Kiev,UA), L Voronkov (Kiev,UA)

Authors:
A Lyashenko1 , P Babich1 , N Tkach1 , L Voronkov1 , 1NSC Institute of Cardiology M.D. Strazhesko, department of heart failure - Kiev - Ukraine ,

Citation:

Background. It is known that  patients with heart failure (HF) demonstrate  high mortality/hospitalization rate. So, the search of  clinical and laboratory predictors of combined endpoint (death or HF hospitalization) potentially may improve  the estimation of their individual prognosis.

 Objective. To establish the predictors of all-cause death/HF hospitalization during 2 – year follow-up in patients with chronic heart failure (CHF) and redused (red) left ventricular ejection fraction (LVEF).

Methods. 134 stable CHF pts (NYHA II-IV, LVEF < 40%)  under optimized standard treatment were examined. Statistics programs package  SPSS 13,0 was used; cluster analysis and logistic regression were used to calculate the predictors.
Conclusion. Plasma  levels of bilirubin, ALT, BUN, NTproBNP,  and citrullin as well as LVEF, SBP, BMI, GFR, FMVR and MHFLQ score are the strong predictors  of critical event (death or HF hospitalization) in CHF with redLVEF.

Results.

Variable

Cut off level

OR

CI

p

Bilirubin, mkmol/l

> 42,5

5,20

1,94- 13,9

0,001

MHFLQ score

> 40,5

3,91

1,73- 8,82

0,001

BMI, kg/m2

< 28,73

3,53

1,69-7,36

0,001

Citrulline, mmol/l

> 111,5

3,39

1,56-7,33

0,003

NTproBNP, pg/dl

> 818,51

3,26

1,33-8,00

0,014

FMVR, %

< 8,77

3,21

1,41-7,29

0,18

GFR, ml/min/1,73 m2

< 57,5

3,00

1,43-6,25

0,005

SBP, mm Hg

< 130

2,91

1,35-6,28

0,009

BUN, mmol/l

> 2,3

2,62

1,30-5,30

0,011

LVEF, %

< 30

2,50

1,22-5,10

0,018

ALT, mmol/l

> 21

2,46

1,19-5,09

0,023

SBP – systolic blood pressure; MHFLQ – Minnesota HF life questionnaire, BUN – blood urea nitrogen, ALT - alaninaminotransferase, BMI - body mass index, GFR – glomerular filtration rate, FMVR – flow-mediated vasodilatory response.

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