In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.

The free consultation period for this content is over.

It is now only available year-round to HFA Silver & Gold Members, Fellows of the ESC and Young combined Members

Differences between diabetics and non-diabetics with chronic heart failure and its impact on prognosis

Session Poster Session 1

Speaker Lenka Spinarova

Event : Heart Failure 2019

  • Topic : heart failure
  • Sub-topic : Chronic Heart Failure – Epidemiology, Prognosis, Outcome
  • Session type : Poster Session

Authors : L Spinarova (Brno,CZ), J Spinar (Brno,CZ), J Parenica (Brno,CZ), M Spinarova (Brno,CZ), O Ludka (Brno,CZ), K Labr (Brno,CZ), F Malek (Praha,CZ), P Ostadal (Praha,CZ), J Jarkovsky (Brno,CZ)

L Spinarova1 , J Spinar2 , J Parenica2 , M Spinarova1 , O Ludka2 , K Labr1 , F Malek3 , P Ostadal3 , J Jarkovsky4 , 1Masaryk University,St. Anne's Faculty Hospital,1st Department of Internal Medicine-Cardioangiology - Brno - Czechia , 2University Hospital and Masaryk university, Internal Cardiologic Dpt - Brno - Czechia , 3Homolka Hospital, Cardiologic Dpt - Praha - Czechia , 4Masaryk University, Faculty of Medicine, Institute for Biostatistics and Analysis - Brno - Czechia ,


The FAR NHL (FARmacology and NeuroHumoraL activation) registry is a database of patients treated in 3 departments with specialized heart failure care in one country. The patients should be treated for systolic heart failure (EF < 50%) and stable for at least one month. It analyses physical status, laboratory tests :blood count, biochemistry, including NT-proBNP, echocardiography and concomitant medication.  Continuous variables are described by median, categorical variables are described by absolute and relative frequencies.P-value of Mann-Whitney U test for continuous variables and P-value of the Fisher’s exact test for categorical variables are reported for comparison of patients’ characteristics according to presence diabetes mellitus. Survival was evaluated after 2 years  of follow-up and defined  as freedom of death or left ventricle assist device  implantation or heart transplantation.

1052 patients were included, and divided to diabetics 409 and non-diabetics 643.  Patients with diabetes were older: 67 (60; 73) vs 64 years (54; 72) ( p< 0.001), had higher BMI 30 (27; 34) vs 28 (25; 31) ( p< 0.001),  higher heart rate 74 (65; 81) vs 71 (64; 80) ( p< 0.01), higher uric acid 412 (351; 477) vs 388 µmol/l (330; 463) ( p< 0.003), lower hemoglobin 141 (130; 151) vs 145 (133; 154) g/l (< 0.001) and lower glomerular filtration 63 (47; 82) vs 73 (57; 89) (ml/min/1.73 m²) (< 0.001). Diabetics had more often ischemic heart disease 70.9 vs 47.3 % ( p< 0.001), hypertension 79.7 vs 55.8%  ( p< 0.001), dyslipidemia 89.0 vs 69.2%  ( p< 0.001). The NT-proBNP levels were signifficantly higher in diabetics 681 (225; 1 708) vs 463 (138; 1 462) ng/l  in non- diabetics (p< 0.003). There were no differences in blood pressure, ejection fraction or presence of atrial fibrillation. Medication for heart failure did not differ in usage of ACEI/ARB, beta blockers and verospiron. Diabetics had more often furosemide 85.8 vs 77.3% (< 0.001). Two year survival was 81.2% in diabetics (77.2; 85.3) vs 86.1% in non- diabetics (83.3; 88.9) p< 0.057.

Conclusion: Diabetics have more often comorbidities: ischemic heart disease, hypertension, dyslipidemia, decreased renal functions and anemia, which contributes to more severe heart failure evaluated by NT-proBNP and  worse prognosis than in non- diabetics with chronic heart failure.

Get your access to resources

Join now
  • 1ESC Professional Members – access all ESC Congress resources 
  • 2ESC Association Members (Ivory, Silver, Gold) – access your Association’s resources
  • 3Under 40 or in training - with a Combined Membership, access all resources
Join now

Our sponsors

ESC 365 is supported by Bayer, Boehringer Ingelheim and Lilly Alliance, Bristol-Myers Squibb and Pfizer Alliance, Novartis Pharma AG and Vifor Pharma in the form of educational grants. The sponsors were not involved in the development of this platform and had no influence on its content.

logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are