Purpose: To study the role of sleep-disordered breathing on ventricular arrhythmias (VA) in postmenopausal women with AH and CAD
Methods: 144 postmenopausal women with AH 1–2 degrees and chronic forms of CAD (mean age 66.6 ± 7.5 years) were examined. 27.1% of women had heart failure (NYHA I-II). The first group included 96 patients with VA. The second group consisted of 48 women without VA. The groups were divided into subgroups: A - index of apnea / hypopnea (AHI) <5 per hour of sleep; B - AHI = 5 per hour of sleep. Patients underwent holter monitoring of ECG and respiratory monitoring.To characterize the VA, the Lown and Wolf classification was used in the Ryan modification. VA 3 and higher gradations were taken to arrhythmias of high gradations.
Results: Patients with sleep-disordered breathing (AHI = 5 per hour of sleep) were found in the I (36.5%) and II (22.9%) groups, but in the group with VA of such patients there was a 13.6% increase (?² with the Yates correction = 1.9 p> 0.05). Patient didn’t significantly differ in the frequency of detection of VA I, III, IV? and V grades (?> 0.05). Frequent ventricular extrasystole (VE) by 22.2% (p <0.01 in the Fisher test) was more often recorded in patients in the IA subgroup (29.9% and 5.7% accordingly). Polymorphic pair VE more often (by 20.8%; p <0.01 by Fisher test) was detected in women of the IB subgroup. In patients with IB subgroups, arrhythmias of high gradations (51.4%) were more frequent (21.9% ?² = 4.56 p <0.05) compared with the IA subgroup.Using the method of calculating the odds ratio, it was found that the AHI = 5 episodes per hour of sleep increases the chance of development of high-grade VA by 2.5 times, polymorphic pair VE by 7 times.
Conclusions:Sleep-disordered breathing (AHI = 5 per hour of sleep) is associated with high-gradation VA and polymorphic paired VE.