Purpose: We sought to assess the impact of BB on cardiovascular outcomes in patients with CAD and no LV dysfunction, hospitalized for acute HF.
Methods: The Gulf-CARE (Gulf aCute heArt failuRe rEgistry) is a prospective multicenter cohort of acute HF in the GULF Middle East.We studied in-hospital cardiovascular events in patients hospitalized for acute HF, with a previous history of CAD and a LVEF =40%, in relation to BB on admission; and one-year outcome in relation to BB on discharge, in the GULF-CARE, a prospective multi-center cohort of acute HF.
Results: From a total of 5005 patients included in the GULF-CARE registry,824 had a previous history of CAD and a LVEF =40%. 303 patients on BB were propensity-matched to 303 patients without BB. Mean age was 65 (11) and 53% were males. BB did not reduce in-hospital mortality (OR= 0.82; 95%CI [0.35-1.94]), stroke, and cardiogenic shock. On discharge, 306 patients on BB – including the ones newly diagnosed for myocardial infarction as a precipitating cause of HF- were propensity-scored matched with 306 patients without BB. Mortality (OR= 0.86; 95%CI [0.51-1.45], hospitalization for HF or PCI/CABG at 12 months were also were also not reduced by BB use at discharge. Further sensitivity analysis showed that BB treatment was not an independent predictor of in-hospital and 12-month mortality.
Conclusions: In this cohort of patients with acute HF, BB do not reduce in-hospital and one-year cardiovascular outcomes in patients with a previous history of CAD and a LVEF =40%.