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Heart failure patients with a higher protein intake live longer

Session Young Investigator Award: Clinical

Speaker Koen Streng

Event : Heart Failure 2018

  • Topic : heart failure
  • Sub-topic : Chronic Heart Failure: Lifestyle Modification
  • Session type : Young Investigator Award Abstracts

Authors : K W Streng (Groningen,NL), JM Ter Maaten (Groningen,NL), K Damman (Groningen,NL), DJ Van Veldhuisen (Groningen,NL), P Van Der Meer (Groningen,NL), JL Hillege (Groningen,NL), AA Voors (Groningen,NL)

Authors:
K W Streng1 , JM Ter Maaten1 , K Damman1 , DJ Van Veldhuisen1 , P Van Der Meer1 , JL Hillege1 , AA Voors1 , 1University Medical Center Groningen - Groningen - Netherlands ,

Citation:

Background: A higher protein intake has been associated with a higher muscle mass and lower mortality rates in the general population, but data about protein intake and survival in HF patients is lacking.

Methods: We studied the association between protein intake and survival in 2516 patients from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF) study were included. Protein intake was calculated  using a validated formula including urea excretion in spot urine, corrected for urine creatinine and body mass index (BMI) (adjusted Maroni formula; 13.9 + 0.907 * BMI (kg/m2) + 0.0305 * urinary urea level (mg/dL)). Association with mortality was assessed using multivariable Cox regression models.

Results: We included 2281 patients with available data (mean age 68±12 years and 27% female). Patients in the highest quartile of protein intake were more often male, had lower NT-proBNP levels and had a higher BMI. Mortality rate in the lowest quartile was 31%, compared to 18% in the highest quartile (P<0.001). In a multivariable model, lower protein intake was associated with a higher risk of death (Hazard ratio (HR) 1.46; 95% confidence interval (CI) 1.01-2.12, P=0.045 for the lowest quartile and HR 1.58; 95% CI 1.19-2.28, P=0.015 for the 2nd quartile.

Conclusions: In patients with HF we found a higher protein intake to be independently associated with a better survival. The potential benefit of a high protein diet in patients with HF warrants further study.

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