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The association of global longitudinal strain with clinical outcomes in heart failure patients with severe left ventricular systolic dysfunction

Session Poster Session 3

Speaker Hye Won Lee

Congress : Heart Failure 2018

  • Topic : heart failure
  • Sub-topic : Chronic Heart Failure - Epidemiology, Prognosis, Outcome
  • Session type : Poster Session
  • FP Number : P1723

Authors : H W Lee (Busan,KR), JC Choi (Busan,KR), JY Shin (Busan,KR), SH Lee (Busan,KR), JH Ahn (Busan,KR), JS Park (Busan,KR), JH Oh (Busan,KR), JH Choi (Busan,KR), HC Lee (Busan,KR), KS Cha (Busan,KR), TJ Hong (Busan,KR)


H W Lee1 , JC Choi1 , JY Shin1 , SH Lee1 , JH Ahn1 , JS Park1 , JH Oh1 , JH Choi1 , HC Lee1 , KS Cha1 , TJ Hong1 , 1Pusan National University Hospital, Department of Cardiology - Busan - Korea Republic of ,


Purpose: The heart failure (HF) patients with severe left ventricular (LV) systolic dysfunction still have unfavorable prognosis.We aimed to investigate if better global longitudinal strain (GLS) predicts improved clinical outcomes in these patients.Methods: Among 293 consecutive HF patients with severe LV systolic dysfunction, defined as LV ejection fraction (LVEF) =30% at baseline echocardiogram, in an urban tertiary center (October 2013-September 2017), the predictive ability of GLS by speckle-tracking echocardiography for the subsequent occurrence of clinical outcomes was evaluated. The primary outcome was composite endpoint of cardiac death and HF readmission.Results: Composite endpoint occurred in 140 patients (47.8%) during a mean 367 days of follow-up. GLS was independently predictive of composite endpoint, but LVEF was not. In the receiver operating characteristic curve analyses of GLS, the cutoff values for predicting composite endpoint were -9.9 % (sensitivity: 0.90; specificity: 0.28; area under the curve: 0.598). Better GLS group (defined as GLS =-9.9%, n=54), compared to worse GLS group (defined as GLS >-9.9%, n=239), had significantly lower rate of composite endpoint (24.1% vs. 53.1%, p<0.001). Composite endpoint-free survival rate was significantly higher in better GLS group than worse GLS group (75.9% vs. 46.9%, log rank p=0.022).Conclusion: GLS may provide the additive information for clinical outcomes in patient with severe LV systolic dysfunction.

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