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2D phase contrast flow in the ascending aorta at 7 tesla: preliminary results

Session Poster Session 3

Speaker Maria Stefanescu

Event : Heart Failure 2018

  • Topic : heart failure
  • Sub-topic : Imaging
  • Session type : Poster Session

Authors : A Kosmala (Würzburg,DE), MR Stefanescu (Würzburg,DE), D Lohr (Würzburg,DE), M Terekhov (Würzburg,DE), LM Schreiber (Würzburg,DE)

A Kosmala1 , MR Stefanescu2 , D Lohr2 , M Terekhov2 , LM Schreiber2 , 1University Hospital Würzburg, Comprehensive Heart Failure Center, Chair of Cellular and Molecular Imaging; Department of Radiology - Würzburg - Germany , 2University Hospital Würzburg, Comprehensive Heart Failure Center, Chair of Cellular and Molecular Imaging - Würzburg - Germany ,

Chronic Heart Failure – Diagnostic Methods: Imaging

Introduction: Due to its high potential there is growing demand for the application of ultra-high field (B0=7T) scanners in cardiovascular magnetic resonance (CMR) imaging, although technical challenges increase significantly with the static magnetic field strength. For evaluation and follow-up of patients with cardiovascular disease, ventricular morphology and function are important clinical parameters, which can be assessed non-invasively and comprehensively using CMR. First studies have shown a high level of agreement for ventricular volumetric parameters measured at 7T and routine clinical field strengths. Another fast way of obtaining basic hemodynamic parameters is 2D phase contrast CMR, which can be used to measure blood flow in the ascending aorta. In the absence of valve disease, the aortic forward flow should resemble the left ventricular stroke volume. However, to date flow parameters in the ascending aorta based on 2D phase contrast measurements at 7T have not yet been validated. Purpose: To assess the agreement between parameters of cardiac function derived from 2D phase contrast measurements in the ascending aorta and left ventricular short axis gradient-echo (GRE) CINE pulse sequences at 7T in healthy subjects. Methods: 11 healthy volunteers (6 female, 5 male) were scanned using a 1TX/16RX thorax coil. Mean subject age was 27.3 years (range 22-39), and body weight 67.6 kg (range 52-92 kg). For triggering both the integrated ECG (n=6) and an external acoustic triggering (n=5) system were used. Sequence parameters for the short axis GRE CINE stack were TE=3.57 ms, TR=30.6–88.3 ms, voxel size 0.6x0.6x6.0 mm, segments 6–11, phases 20–35, slices 14–17. The parameters for the phase contrast sequence were TE=98.9 ms, TR=3.2 ms, voxel size 1.5x1.5x6.0 mm, segments 7-9, phases 20–25, VENC=150 m/s. Volumetric and flow analyses were performed on an integrated scanner-side software. Agreement between stroke volume und aortic forward flow was analysed using the Pearson correlation coefficient and a two-sided t-test. Results: Mean left ventricular stroke volume determined by CINE sequences was 74.9 ml (standard deviation (SD) 11.3 ml) and mean forward flow in the ascending aorta based on phase contrast imaging was 73.9 ml (SD 10.8 ml), showing no significant difference (p=0.52) and a strong positive correlation (r=0.91) (Figure 1). Conclusion: We found a high level of agreement between stroke volume based on short axis GRE CINE sequences and aortic forward flow derived from 2D phase contrast imaging at 7T. This suggests that phase contrast CMR at 7T can correctly quantify ascending aortic flow and thus may play an important role in potential future clinical assessment of valve disease and cardiac function at 7T. However, a larger patient sample, in particular of patients with cardiac disease is essential for improving clinical acceptance. Moreover, validation against flow parameters acquired at routine clinical field strengths is necessary.

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