In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.

The free consultation period for this content is over.

It is now only available year-round to HFA Silver & Gold Members, Fellows of the ESC and Young combined Members

Status of vitamin D in difficult to treat cardiorenal syndrome in heart failure patients.

Session Poster Session 1

Speaker Naresh Sen

Event : Heart Failure 2018

  • Topic : heart failure
  • Sub-topic : Chronic Heart Failure: Comorbidities
  • Session type : Poster Session

Authors : N Sen (Jaipur,IN), SONAL Tanwar (Jaipur,IN), ASHOK Jain (Jaipur,IN)

Authors:
N Sen1 , SONAL Tanwar2 , ASHOK Jain1 , 1Narayana Hrudayalaya, Cardiology - Jaipur - India , 2HG SMS Hospital, Cardiology - Jaipur - India ,

Citation:

Background:  Decreased glomerular filtration rate(GFR)  is a potent predictor of cardiovascular mortality and complications. Worsening heart failure can accelerate worsening of renal function – the so-called cardiorenal syndrome. Risk factors include hypertension, diabetes, elderly age, and prior history of heart or renal failure.
Aims & Objectives:  To study the correlation between serum vitamin D values in uncontrolled cardiorenal syndrome and to evidential improvement in control of cardiorenal syndrome after vitamin D supplementation and correlate it with heart & renal function.
Methods: Serum vitamin D levels were assessed in 178 patients of cardiorenal syndrome in duration of 2 years (2015-2017) and we found very low level of vitamin D ( average level was 16 U ng/ml )  in 108 patients of difficult to treat cardiorenal syndrome between 19 -74 years of age who were uncontrolled even after courses of Betablocker, Diuretics and ACE inhibitors or Angiotensin II Receptor Blocker Neprilysin Inhibitor (ARNI) and other optimised medical therapy . These patients were treated with calcium and Vitamin D supplementation for 12 weeks  and after were re-evaluated with repeat vitamin D levels, Renal function test , GFR and Cardiac functions by 2D Echocardiography .
Results: All  108  patients showed significant improvements in B-type natriuretic peptide (BNP level), Right and Left ventricular function, LVEF incresed (14+/-4%) , decreased pulmonary capillary wedge pressure and improved class of dyspnea New York Heart Association IV to class II or III. After 3 months of vitamin D supplementation 43% patients had improved GFR and serum creatinine value as compare to placebo 16% , p value(<0.003).
Conclusion:  Study showed  a strong correlation between vitamin D deficiency and difficult to manage cardiorenal syndrome and good cardiorenal outcome after supplementation.

The free consultation period for this content is over.

It is now only available year-round to HFA Silver & Gold Members, Fellows of the ESC and Young combined Members

Get your access to resources

Join now
  • 1ESC Professional Members – access all ESC Congress resources 
  • 2ESC Association Members (Ivory, Silver, Gold) – access your Association’s resources
  • 3Under 40 or in training - with a Combined Membership, access all resources
Join now

Our sponsors

ESC 365 is supported by Bayer, Boehringer Ingelheim and Lilly Alliance, Bristol-Myers Squibb and Pfizer Alliance, Novartis Pharma AG and Vifor Pharma in the form of educational grants. The sponsors were not involved in the development of this platform and had no influence on its content.

logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are