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Thromboembolic events in left ventricular non-compactation cardiomyopathy, are there any predictors?

Session Comorbidities and cardiomyopathies - How to manage?

Speaker Nuno Craveiro

Event : Heart Failure 2018

  • Topic : valvular, myocardial, pericardial, pulmonary, congenital heart disease
  • Sub-topic : Dilative Cardiomyopathy
  • Session type : Rapid Fire Abstracts

Authors : N Craveiro (Santarem,PT), H Antunes (Viseu,PT), N Marques (Faro,PT), L Reis (Coimbra,PT), R Santos (Evora,PT), AR Almeida (Penafiel,PT), O Azevedo (Guimaraes,PT)

Authors:
N Craveiro1 , H Antunes2 , N Marques3 , L Reis4 , R Santos5 , AR Almeida6 , O Azevedo7 , 1Hospital of Santarem, Cardiology - Santarem - Portugal , 2Hospital Sao Teotonio - Viseu - Portugal , 3Algarve Biomedical Center, Centro hospitalar do Algarve, Cardiology - Faro - Portugal , 4University Hospitals of Coimbra - Coimbra - Portugal , 5Hospital Espirito Santo de Evora - Evora - Portugal , 6Hospital Centre do Tamega e Sousa - Penafiel - Portugal , 7Hospital Guimaraes - Guimaraes - Portugal ,

On behalf: SUNSHINE

Citation:

Introduction: Patients with left ventricular non-compaction cardiomyopathy (LVNC) have a higher prevalence of heart failure, ventricular arrhythmias and thromboembolic events leading to increased mortality and morbidity.

Aim: To identify predictors of thromboembolic events in patients with LVNC.

Methods: One-hundred-eleven-patients (N=111) diagnosed with LVNC were included from a Portuguese multicenter study involving 12 hospital centers. We evaluated demographic, clinical, electrocardiographic, echocardiographic and cardiac magnetic resonance, and follow-up data. We determined the factors and conducted a multivariate analysis to establish the independent predictors that were associated with the occurrence of thromboembolic events in these patients.

Results: A thromboembolic event occurred in 10 patients (9%). In our study the factors associated with a thromboembolic event were male gender (90% p=0,042), presence of diastolic dysfunction as evaluated by deceleration time (200±81 ms vs 191±44 ms, p=0,001) and left atrium volume (40,58±16,6 ml/m2 vs 30,4± 11,7 ml/m2 p=0,036), as well as older age of diagnosis (60,4±13,9 years vs 45,13±17,7 years p=0,010) and the presence of sustained ventricular tachycardia in Holter monitoring (p=0,03). After multivariable analysis the only independent predictor of thromboembolic event was the presence of sustained ventricular tachycardia in Holter monitoring (Beta=0,334; p=0.016).

Conclusion: Thromboembolic events are frequently associated with LVNC. In our population the incidence of thromboembolism was 9%. The presence of sustained ventricular tachycardia in Holter monitoring was an independent predictor of events in our study.

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