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Inverse relationship between hemoglobin oxygen saturation measured by pulse oximetry at rest and exercise capacity in the patients with heart failure

Session Poster session 3

Speaker Naoki Aizawa

Event : Heart Failure 2017

  • Topic : preventive cardiology
  • Sub-topic : Exercise Testing
  • Session type : Poster Session

Authors : N Aizawa (Nishihara,JP), K Nagahama (Okinawa,JP), Y Toma (Nishihara,JP), H Ikemiyagi (Nishihara,JP), T Shinzato (Nishihara,JP), M Iwabuchi (Nishihara,JP), Y Ohya (Nishihara,JP)

N Aizawa1 , K Nagahama2 , Y Toma1 , H Ikemiyagi1 , T Shinzato1 , M Iwabuchi1 , Y Ohya1 , 1University of the Ryukyus, Department of Cardiovascular Medicine, Nephrology and Neurology. - Nishihara - Japan , 2Okinawa Rehabilitation Center Hospital - Okinawa - Japan ,

European Journal of Heart Failure ( 2017 ) 19 ( Suppl. S1 ), 493

Background: Exercise capacity is a key prognostic factor in the patients with heart failure (HF). Although peak oxygen consumption (peak VO2) measured by maximal symptom-limited cardiopulmonary exercise test (CPET) is the most objective method to determine exercise capacity, a simple tool to predict exercise capacity is required. Hemoglobin oxygen saturation measured by pulse oximetry (SpO2) is a simple and useful tool to evaluate oxygenation. However, the relationship between SpO2 at rest and exercise capacity measured by CPET is unclear.  
Purpose: To investigate the relationship between SpO2 at rest and exercise capacity measured by maximal symptom-limited CPET in the patients with HF.
Methods: We examined the association between SpO2 and exercise capacity among 46 patients with HF (age 54 ± 13, male 76%, cardiomyopathy 43%, valvular heart disease 35%, ischemic heart disease 17%) who underwent maximal symptom-limited CPET in our institute.
Results: Peak VO2/weight and peak respiratory exchange ratio were 16.2 ± 5.6 ml/min/kg and 1.2 ± 0.1, respectively. SpO2 at rest inversely correlated with peak VO2/weight (r = -0.43, P = 0.003). Compared with the patients who had preserved exercise capacity (peak VO2/weight = 11.0 ml/min/kg, n = 39), the patients who had low exercise capacity (peak VO2/weight < 11.0 ml/min/kg, n = 7) showed significantly higher SpO2 at rest (99.0 ± 0.8 vs 98.0 ± 1.6 %, P = 0.03). Multiple regression analysis revealed that higher SpO2 at rest (ß = -0.29, P = 0.006), age, BMI and lower hemoglobin, sodium are independent predictors of lower peak VO2/weight. 
Conclusion: In patients with HF, higher SpO2 at rest may detect lower exercise capacity.

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