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Ivabradine and heart failure: experience from a real practice
L Mircheva1
,
YY Yotov1
,
YB Bocheva2
,
1Medical University of Varna - Varna - Bulgaria
,
2University Hospital St. Marina, Clinical Laboratory, UMHAT St. Marina, Varna, Bulgaria - Varna - Bulgaria
,
Topic(s): Chronic heart failure - management
Citation:
European Journal of Heart Failure
(
2017
)
19
(
Suppl. S1
),
406
Introduction: Chronic heart failure (CHF) is the most common diagnosis at admission in patients above 65 years. The introduction of ivabradine as a new medication is expected to cope with HF.
Aim: To assess the effect of ivabradine (Iv) after 6 months in patients with CHF NYHA class III-IV post hospitallization.
Materials: We followed 180 patients with CHF for 6 months in an out-patient program. Of them, 80 were in sinus rhythm (SR). The baseline and 6 months levels of NTproBNP, ejection fraction (EF), 6 min walking test (6MWT), NYHA functional class, and renal function were evaluated.
Results: Iv was initiated in 40.3% of patients with SR. After 6 months, the 6MWT improvedt (62.5 m in the Iv vs 23.5 m in the non-Iv group; p=0.043), NTproBNP reduced with median 680 pg/ml and 552,5 pg/ml (p=NS), respectively, and EF increased in Iv with 4.02% and decreased with 1.14% in non-Iv, p=0.06. After 6 months, 77% of the Iv patients were in class II, whereas only 45% of the controls were in class I-II (p=0.023).
Conclusions: Ivabradine in CHF leads to subjective improvement, increases the systolic function, improves the quality of life and functional NYHA class.
ESC Professional Members, Association Members (Ivory & above) benefit from year-round access to all the resources from their respective Association, and to all content from previous years. Fellows of the ESC (FESC), and professionals in training or under 40 years old, who subscribed to a Young Combined Membership package benefit from access to all ESC 365 content from all events, all editions, all year long. Find out more about ESC Memberships here.
