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Remote ischemic preconditioning during rehabilitation in coronary artery disease patients after percutaneous coronary interventions

Session Poster session 4 Tuesday 08:30 - 12:30

Speaker Nadezda Lyamina

Event : Heart Failure 2015

  • Topic : basic science
  • Sub-topic : Basic Science - Cardiac Diseases
  • Session type : Poster Session

Authors : N Lyamina (Saratov,RU), E Kotelnokova (Saratov,RU), E Bizyaeva (Saratov,RU), V Senchikhin (Saratov,RU), S Lyamina (Moscow,RU)

Authors:
N Lyamina1 , E Kotelnokova1 , E Bizyaeva1 , V Senchikhin1 , S Lyamina2 , 1Saratov Scientific Research Institute of Cardiology - Saratov - Russian Federation , 2Moscow State University of Medicine and Dentistry - Moscow - Russian Federation ,

Citation:
European Journal of Heart Failure Abstracts Supplement ( 2015 ) 17 ( Supplement 1 ), 439

It is known that moderate ischemia or repeated short-time ischemic interventions are pathogenetic reasonable and clinically perspective for increasing adaptive reserve of the organism, treatment and prevention of pathologic conditions determined by lack of oxygen, as of coronary artery disease (CAD) patients in different stages of management and rehabilitation. Objective: evaluate the application of remote ischemic preconditioning (IP) in CAD patients with incomplete anatomic revascularization after percutaneous coronary interventions (PCI) during early rehabilitation. Material and methods: We examined 19 CAD patients (14 men, 5 women) aged 40-65 with incomplete anatomic revascularization after PCI. Instrumental methods of examination included ECG, Holter ECG monitoring, diagnostic treadmill stress-test according the protocol of  R.Bruce. Holter ECG monitoring results were used to assess ST index, depth and duration of ST depression, myocardial ectopic activity. Remote IP was performed according to fixed protocol: distal vessels (arm) were cuff compressed with interleaving up to 4 times for 3 minutes and reperfused up to 4 times for 3 minutes. Mean duration of the procedure was 24 minutes. Remote IP was performed no less than 5 times with no less than 48 hours between the procedures. Oxymeter was used for oxygenation control on distal vessels. Safety assessment during the whole period of monitoring was performed by markers of myocardial necrosis and ischemia and by results of instrumental examination. Results. Course of 5 remote IP sessions in CAD patients with incomplete anatomic revascularization after 5-8 days of PCI decreased ectopic activity by 1.6 times and decreased the severity of heart rhythm disorders. The courses of remote IP performed according to the protocol in CAD patients with incomplete anatomic revascularization downsized ischemic signs: the depth of ST depression was reduced by 20.5% and ST index - by 17%.

Conclusions: Remote IP on brachial artery in CAD patients with incomplete anatomic revascularization performed in the first week of outpatient recovery period after PCI and repeated no less than 5 times with intervals between them no less than 48 hours shows anti-arrhythmic and anti-ischemic effects.

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