The purpose of study was to evaluate of plasma fibronectin (FN) levels in patients with chronic heart failure (HF) and its relations with other heart failure signs.
Materials and methods: 389 patients with HF of ischemic genesis and 30 apparently healthy persons (control) were observed. The FN plasma level was detected by ELISA method. Endogenous intoxication was detected by erythrocyte absorption test. Analyses were performed with Statistica system software, version 12.0.
Results: The average age of observed patients was (68,2 ± 11,9) years. Due New York Heart Association criteria the following functional classes of HF were diagnosed: II FC - in 64 patients (16,5%), III FC - in 258 patients (66,3%), IV FC - in 67 patients (17,2%). The average period of HF was 10,0 [5,0; 15,0] years. 277 (71,2%) patients had history of myocardial infarction (MI), and 27 (6,9%) of them had recurrent MI. In 195 (50,1%) patients the second class of stable angina was verified. 107 (27,5%) patients had third functional class of angina. The more often comorbidities in observed patients with HF were: arterial hypertension (AH) - in 308 (78,9%) persons; 2 type Diabetes Mellitus - in 79 (20,3%) persons; chronic kidney disease - in 76 (19,5%) cases; atrial fibrillation - in 32 (8,2%) patients; peripheral artery disease - in 19 (4,9%) patients; history of stroke - in 34 (8,7%) persons. The average FN level in HF patients was higher for 1,24 times compare control group: (257,68 ± 7,24) µg/mL vs (207,56± 13,62) µg/mL (p < 0,05). We also verified of more higher concentration of FN in patients with atrial fibrillation: (354,60 ± 27,19) µg/mL compare (259,55 ± 7,88) µg/mL in patients with sinus rhythm (p < 0,01). During HF progression the FN plasma levels was increased at II-III FC (NYHA), but decreased at FC IV. The lineal multiply regression analysis showed the more important links between FN and endogenous intoxication, left atrium size and end-systolic volume of left ventricle. Conclusions. The ischemic heart failure is characterized by high fibronectin plasma levels. The highest fibronectin concentration was detected in patients with atrial fibrillation. The most important risk-factors for fibronectin level are endogenous intoxication, left atrium size and end-systolic volume of left ventricle.