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Assessment of the factors of angiogenesis in patients with arterial hypertension and coronary artery disease

Session Poster Session 3

Speaker Svetlana Glova

Congress : EuroPrevent 2019

  • Topic : hypertension
  • Sub-topic : Hypertension - Treatment
  • Session type : Poster Session
  • FP Number : P764

Authors : SE Glova (Rostov-on-Don,RU), LA Khaisheva (Rostov-on-Don,RU), SV Shlyk (Rostov-on-Don,RU)

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Authors:
SE Glova1 , LA Khaisheva1 , SV Shlyk1 , 1State Medical University of Rostov-on-Don - Rostov-on-Don - Russian Federation ,

Citation:

Purpose. Assessment of the factors of angiogenesis in patients with arterial hypertension (AH), coronary artery disease (CAD) and acute coronary syndrome (ACS).

Materials and methods: 82 patients and 19 healthy volunteers were examined. The patients were divided into three groups: I - 28 people with AH, mean age 55,00±1,80 years, II - 22 patients - patients with AH and CAD, mean age - 64,68±2,60 years, III - 32 people with AH and ACS - 32 patients, mean age, 48±1,84 years. To conduct the enzyme immunoassay, reagents Bender Medsystems (USA) VEGF were used. The concentration of the test substance was obtained by calculation from the optical density values using the MathCad program in accordance with the instructions of the reagent manufacturer. Statistical processing of data was carried out using statistical analysis program Statistica 6.0 (Statsoft, USA).

Results of the study: mean VEGF levels were not different in patients with AH and relatively healthy volunteers: 196,04±17,17 pg / ml in patients with AH (fluctuations from 22,04 to 834,05 pg / ml) and 176, 78±14,34 pg / ml in healthy volunteers, their scatter is much lower - from 56,23 to 303, 12 pg / ml. The level of endostatin was significantly higher among patients with elevated blood pressure than in the relatively healthy 313,73±13,34 and 97,42±7,25, with p <0,05, respectively. In patients with AH and ACS, the maximum values of VEGF are significantly lower in patients of group 1 (only AH), with no difference in the level of VEGF among patients with AH and CAD when comparing them with patients of the 1st and 3rd groups, i.e. they occupy an intermediate position. The maximum values of endostatin were among patients who underwent ACS, minimal - with CAD and intermediate - in patients of the 1st group, all the differences are reliable.

Conclusions: when comparing the levels of angiogenesis factors in blood, the survey showed that in patients with AH and ACS, the maximum values of VEGF are significantly lower in patients of Group I, the difference in VEGF level among patients with AH and CAD when comparing them with patients I and III groups were not identified, i.e. they occupy an intermediate position. The maximum values of endostatin were among patients who underwent ACS, minimal - with CAD and intermediate - in patients of Group I, all differences are reliable.



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