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Detection of muscle dysfunction in coronary heart disease patients: a randomized clinical trial comparing high versus moderate-intensity aerobic exercise

Session Poster Session 3

Speaker Koldo Villelabeitia

Congress : EuroPrevent 2019

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Coronary Artery Disease - Other
  • Session type : Poster Session
  • FP Number : P709

Authors : K Villelabeitia (Madrid,ES), D Vicente-Campos (Madrid,ES), A Berenguel-Senen (Toledo,ES), B Lopez-Cabarcos (Madrid,ES), C Lazaro Gomez (Madrid,ES), A Nunez-Cortes (Madrid,ES), V Hernandez-Jimenez (Madrid,ES), J Lopez-Chicharro (Madrid,ES)


K Villelabeitia1 , D Vicente-Campos2 , A Berenguel-Senen3 , B Lopez-Cabarcos1 , C Lazaro Gomez1 , A Nunez-Cortes1 , V Hernandez-Jimenez1 , J Lopez-Chicharro4 , 1Hospital Infanta Elena - Madrid - Spain , 2Universidad Francisco de Vitoria. - Madrid - Spain , 3Hospital Virgen de la Salud - Toledo - Spain , 4Complutense University of Madrid, Grupo FEBIO - Madrid - Spain ,


Background: Mechanical efficiency (ME) refers to the ability of an individual to transfer energy consumed by external work. Individuals with lower ME values should be less efficient respect to performance and may therefore be limited in terms of physical activity Most studies that assess the efficiency of the different cardiac rehabilitation exercise programs evaluate the modification of the cardiovascular risk factors, quality of life and clinical variables associated with the prognosis of morbidity and mortality, but there are very few research that evaluates ME, even though it provides important information concerning biomechanical adaptations and the use of the energy sources associated with clinical training and therefore the functional capacity of patients.

Purpose:  The evaluating ME may be valuable in order to the detection of muscle dysfunction and the assessment of any subsequent adaptations in response to training. This study aimed to compare the influence of 2 different exercise protocols: moderate continuous training (MCT) versus high intensity interval training (HIIT), as part of a cardiac rehabilitation program on ME values among coronary patients.

Methods: All patients underwent exercise testing with a cycle ergometer including analysis of exhaled gases. Patients were randomized on a one-to-one basis to either the MCT or the HIIT group. The mode of exercise training was a cycle ergometer with 40 minutes per sessions, 3 days per week (total of 24 sessions over 2 months). Selected CPET variables and ME measurement were recorded before and after the exercise program. ME (expressed as a percentage) was calculated during an incremental maximal cycling test at stages corresponding to VT1, VT2 and VO2peak.

Results: A total of 110 patients were included and studied (53 patients in MCT-group and 57 patients in HIIT-group). Both exercise programms significantly increase VO2peak with a higher increase in the HIIT group (2,96±2,33 ml/kg/min vs 3,88±2,40 ml/kg/min, for patients of the MCT and HIIT groups respectively, p<0,001). The ME at VO2peak and VT2 only significantly increased in the HIIT group (p<0,001).. At VT1, ME significantly increased in both groups, with a greater increase in the HIIT group (2,20±6,25 % vs 5,52±5,53 %, for patients of the MCT and HIIT groups respectively, p<0,001).

Conclusions: The application of HIIT to patients with chronic ischemic heart disease of low risk resulted in a greater improvement in VO2peak and in ME at VT1, than when MCT was applied. Moreover, only the application of HIIT brought about a significant increase in ME at VT2 and at VO2peak.

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