Methods: INEV@L, an ongoing prospective multidisciplinary study, included 156 patients aged < 65 y, currently working and hospitalized for stroke or MI between 1st January 2016 and 31st august 2017. PSF were examined (perceived CV disease severity, anxiety/depression, perceived stress at work (PSW), quality of life at work (QLW) through validated questionnaires and semi-conducted interviews. Patients with higher (supramedian) perceived stress at work (PSW) were compared to lower (inframedian) PSW.
Results: The 156 patients included (121(78%) acute MI, 35(22%) stroke) had a median(IQR) age at 53(48-58) years, 18% were women, 56% smokers. They had high PSW (15(10-20)), but a low QLW (85(75-95)). Patients with high PSW had similar risk factors including age (p=0.450), women (0.542), hypertension (p=0.791), smoking (p=0.384), diabetes (p=0.193), obesity (p=0.995) than patients with lower PSW. Although high PSW patients showed a trend toward lower education level (p=0.067), marital status, and socioeconomic categories were similar for both groups. Elevated perceived disease severity was more common (49 vs 29%, p=0.011) in stressed patients. Patients with high PSW are more anxious (78 vs 25%, p<0.001), and had twice more depressive symptoms (19 vs 9%, p=0.100). QLW was significantly lower in high PSW patients (81±16 vs 90±13, p<0.001). Moreover, QLW was strongly correlated with PSW (r=-0.433, p<0.001). Conclusion: These preliminary data from a prospective pilot study shows a high PSF burden in patients hospitalized for acute CVE. If confirmed at a larger scale, our data could identify new opportunities for secondary preventive strategies.