Purpose: To assess the effect of physical activity on the risk of all-cause mortality in patients with CAD after coronary stenting.
Methods: The study included 977 patients with CAD (741 men and 236 women, mean age 58.6±9.4 years) who underwent coronary stenting. Mean duration of follow-up was 12.0±1.8 months. International Physical Activity Questionnaire (IPAQ) Short Forms was used to assess physical activity. According to the IPAQ Short Forms, there were defined three categories of physical activity: low, moderate and high.
The relationship between mortality and physical activity was evaluated using Cox proportional hazards model. Hazard ratio (HR) and 95% confidence intervals (CI) were calculated after adjustment for the following confounders: age, gender, systolic and diastolic blood pressure, body mass index, smoking status, alcohol abuse, total cholesterol, severity of heart failure and presence of acute coronary syndrome at admission and severity of coronary lesions by SYNTAX score.
Results: Low physical activity was observed in 39.5% of patients, moderate physical activity in 32.1% of patients and high physical activity in 28.4% of patients. During the prospective study period 24 patients (2.5%) died. After adjusting for all confounding factors, risk of all-cause mortality was significantly higher in patients with low physical activity: HR=4.60 (95% CI 1.02 – 20.7) compared to patients with high physical activity. The multivariate HR for patients with moderate physical activity was 2.93 (95% CI 0.60 – 14.4).
Conclusion: Low physical activity was independently associated with higher risk of all-cause mortality in patients with CAD after coronary stenting.