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Impact of depression as predictor of cardiorespiratory fitness in cardiac patients before and following cardiac rehabilitation

Session Poster Session III - Saturday 08:30 - 12:30

Speaker Nicolai Mikkelsen

Event : ESC Preventive Cardiology (Formerly EuroPrevent) 2017

  • Topic : preventive cardiology
  • Sub-topic : Stress, Psycho-Social and Cultural Aspects of Heart Disease
  • Session type : Poster Session

Authors : N Mikkelsen (Copenhagen,DK), H Rasmusen (Copenhagen,DK), A Holdgaard (Copenhagen,DK), E Prescott (Copenhagen,DK)

N Mikkelsen1 , H Rasmusen1 , A Holdgaard1 , E Prescott1 , 1Bispebjerg University Hospital, Department of Cardiology - Copenhagen - Denmark ,

European Journal of Preventive Cardiology ( April 2017 ) 24 ( Supplement 1 ), 162

Background: Cardiorespiratory fitness (CRF) is an important predictor for all-cause mortality and morbidity. Cardiac rehabilitation (CR) improves CRF and decreases cardiac morbidity and mortality. Cardiac patients with depression have less compliance with CR programs and benefit less from CR.
Purpose: To determine whether depression is associated with CRF and predicts poorer effect of CR
Methods: Retrospective cohort study of 1217 cardiac patients with ischemic heart disease, valvular heart disease, or heart failure referred for cardiac rehabilitation at Bispebjerg/Frederiksberg hospital in Denmark. CRF was measured as VO2max (ml/kg/min) by a maximal cardiopulmonary exercise test. Pre-existing depression was defined by use of antidepressants and new depression by a modified MD-PRIME questionnaire at baseline.
Results: Patients with new depression were approximately five years younger than non-depressed and patients with pre-existing depression (<0.001). Women were more likely to have both types of depression (<0.001), whereas patients with other ethnicity than Danish were more likely to have new depression (<0.001). After multivariable adjustment gender, age, educational attainment and working status, ethnicity and co-morbidity were predictors of baseline CRF. There was no significant difference in CRF between those with pre-existing depression (-1.04 ml/kg/min, p=0.10) or new depression (0.25 ml/kg/min, p=0.71). Mean improvement of CRF following CR was 2.38 (2.13-2-64) ml/kg/min. Multivariable adjusted results are shown in table.
Conclusion: Having pre-existing depression and new depression did not influence CRF either before or after CR.

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