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Associations between glucose and all-cause mortality according to the presence of diabetes mellitus among the population of 55 years and older.

Session Poster Session III - Saturday 08:30 - 12:30

Speaker Yulia Balanova

Congress : EuroPrevent 2017

  • Topic : preventive cardiology
  • Sub-topic : Lipids
  • Session type : Poster Session
  • FP Number : 676

Authors : A Imaeva (Moscow,RU), S Shalnova (Moscow,RU), A Deev (Moscow,RU), Y Balanova (Moscow,RU), A Kapustina (Moscow,RU), G Muromtseva (Moscow,RU), D Smirnov (Moscow,RU), V Shkolnikov (Rostock,DE)

Authors:
A Imaeva1 , S Shalnova1 , A Deev1 , Y Balanova1 , A Kapustina1 , G Muromtseva1 , D Smirnov1 , V Shkolnikov2 , 1National Research Center for Preventive Medicine, Department of Epidemiology of Chronic Non-Communicable Diseases - Moscow - Russian Federation , 2Max Plank Institute for Demographic Research - Rostock - Germany ,

Citation:
European Journal of Preventive Cardiology ( April 2017 ) 24 ( Supplement 1 ), 144

Aim: Evaluate associations between various levels of glucose and all-cause mortality according to the presence of diabetes mellitus among the population of 55 years and older. Material and methods. This study is part of the prospective cohort survey "Stress, aging and health." 1876 participants (489 with diabetes mellitus (DM)) aged 55 years and older were included. All participants were divided into 10 groups according to the quintiles of blood glucose and the presence of DM. Diagnosis of DM was based on the history of DM or levels of glycated hemoglobin >6.5%. The mean follow-up was 7.05 years, 411 deaths occurred (293 among participants without DM and 118 among population with DM). Association between glucose and all-cause mortality was evaluated by Cox regression model.
Results: The relative risk for all-cause mortality was significantly higher among individuals without DM and with glucose levels below 5.1 mmol/l, after adjustment for sex and age. These associations remained significant even after additional adjustment for coronary artery disease and/or traditional risk factors. The most significant decrease in all-cause mortality was observed in individuals without DM and with glucose level 5.5-5.9 mmol/l. Elevated glucose was associated with increased mortality, but not significantly. At the same time there was no significant association between glucose and all-cause mortality among participants with DM.
Conclusion: L-shaped association of glucose with all-cause mortality was found among the population 55 years and older without diabetes mellitus. The lowest risk of all-cause mortality was observed among individuals without DM and with glucose levels 5.5 – 5.9 mmol/l. No significant association between glucose and all-cause mortality among participants with DM was found.



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