In line with the ESC mission, newly presented content is made available to all for a limited time (4 months for ESC Congress, 3 months for other events). ESC Professional Members, Association Members (Ivory & above) benefit from year-round access to all the resources from their respective Association, and to all content from previous years. Fellows of the ESC (FESC), and Professionals in training or under 40 years old, who subscribed to a Young Combined Membership package benefit from access to all ESC 365 content from all events, all editions, all year long. Find out more about ESC Memberships here.
Features of the vascular remodeling in men with prehypertension
The ESC does not have the copyright for the slides and video of this presentation
1Altay State Medical University - Barnaul - Russian Federation
2Railway Clinical Hospital - Barnaul - Russian Federation
Aim: to explore the features of vascular remodeling in patients with prehypertension compared with hypertension. All patients were divided into groups: the 1-st - 30 men with prehypertension (PHTN), second - 30 men with diagnosed hypertension (HTN), control group-30 healthy volunteers. The age was 46.1±8.3, 47.7±8.5 and 48.1±7.4 years. The CV risk factors, atherosclerosis markers, endothelium dependent vasodilatation (EDVD) were evaluated. The arterial stiffness and central systolic blood pressure (CBP) were performed on the SphygmoCor (AtCor Medical Pty Limited.). Results. PHTN patients were at a comparable rate of modifiable risk factor, has a lower incidence of abdominal obesity (16%), compared to the HT patients - (40%) (p <0.05). ABI <0.9 was found in 30% and 38% of patients in the 1st and 2nd group, 18% in the control group (p <0,005). IMT was 0,7 ± 0,02 and 0,8 ± 0,08 mm in both groups. Carotid atherosclerosis were diagnosed in 30% of the PHTN and 55% of HTN (p <0,005), 17% in the control (p <0,005). Endothelial dysfunction was found in 57.6% In the 1st group and in 42.4% in 2nd (?2 = 5,6, p <0.05). The combination of endothelial dysfunction and atherosclerosis was in the 54.3% for the 1st group and 82,1% - 2nd , (p <0,05). Arterial stiffness index (SI) was 5,5 ± 1,85 m/s in the control group, 7,20±1,99 m/s in the 1st group, 8,90±1 85 m/s in the 2nd, which is higher than in the control group (p <0,005). The reflection index (RI) was higher in the both test groups compared to control (35,46 ± 14,50%, 36,59 ± 15,43% and 30,39 ± 13,43% respectively, p <0,005). AI in the groups was comparable with healthy volunteers. PWV> 10 m/s was found in 3% and 5% in the 1st and 2nd groups, respectively. According to the age, among the 31-50 years old patients, 80% in the 1st group and 70% in the 2nd had a higher then a normal PWV (6.6 m/s). At the age of 50, 66% in the 1st group and 50% in the 2nd group had the result higher than 8.5 m/s. AIx and AIx75 in HT patients were higher than in the control group by 10% (p <0,005), Spa at 20 mm Hg (p <0,005). Conclusions. PHTN men under the age of 55 years have a lower incidence of carotid atherosclerosis and comparable signs of lower limbs atherosclerosis, comparable incidence of arteriosclerosis. However, these figures differ from healthy patients. Already at the age of 31-50 years, the majority of patients (80%) have indicators of vascular stiffness, not corresponding to the normal values. In these patients there is a tendency to increasing CBP. Endothelial dysfunction in PHTN is more common than in patients with hypertension, but it is less combined atherosclerosis.
ESC 365 is supported by Bayer, Boehringer Ingelheim and Lilly Alliance, Bristol-Myers Squibb and Pfizer Alliance, Novartis Pharma AG and Vifor Pharma in the form of educational grants. The sponsors were not involved in the development of this platform and had no influence on its content.
Our mission: To reduce the burden of cardiovascular disease