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Differences in an adjusted index of diastolic function in apparently healthy obese young patiens

Session Poster Session III - Friday 08:30 - 12:30

Speaker Raul Gascuena

Event : ESC Preventive Cardiology (Formerly EuroPrevent) 2015

  • Topic : preventive cardiology
  • Sub-topic : Risk Factors and Prevention
  • Session type : Poster Session

Authors : R Gascuena (Madrid,ES), M Molina (Madrid,ES), N Acosta (Madrid,ES), C Novo (Madrid,ES)

Authors:
R Gascuena1 , M Molina1 , N Acosta1 , C Novo1 , 1Hospital Universitario Severo Ochoa - Madrid - Spain ,

On behalf: CARDIOSAN

Citation:

An adjusted index of  diastolic function, easily determined by tissue doppler velocities measured at the level of mitral annulus (Ea/(Sa x Aa)), showed prognostic value in general population. Nevertheless, its value has not been sufficiently studied in population at risk. Obesity carries out a higher risk. We study the presence of differences in this index in a population of apparently healthy obese patients.

Methods: 376 patients (44.7% from them with obesity, Body Mass Index  33,9 vs 25.7),  without a known cardiovascular disease were studied by conventional and tissue Doppler echocardiography. Anthropometric, biochemical and blood pressure mesurements were obtained, and risk score determined (DORICA score, a Framingham formula validated on Spanish bariatric surgery patients). The adjusted index of diastolic function and the rest of parameters were compared between obese and not obese patients. Predictors for that index were investigated by linear regression methods, considering the above mentioned parameters, sex, age, and heart rate.

Results: Mean age was 42.2 years. 85% were male. We found no differences in cardiac dimensions indexed by body surface. Left ventricle from obese patients was slighty more hyperdinamic (LVEF 74 vs 69%;p 0.012) . The adjusted diastolic index was a 20.41% inferior in obese patients (0.1057, SD 0.05 vs. 0.1328, SD 0.06) (Difference of means 0.027;IC95% 0.01-0.044)(p 0.001).

 The predictor factors for this index were Body Mass Index, Abdominal Perimeter, Total Cholesterol Levels, and the DORICA Risk Score.

Conclusions: The Adjusted Index of Diastolic Function determined by tissue Doppler was diminished in obese patients. This index correlates with Risk Score and Total Cholesterol. Its prognostic value is being investigated in this on-going study.

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