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The activity of eosinophils in patients with coronary atherosclerosis

Session Poster Session III - Friday 08:30 - 12:30

Speaker Fariza Byazrova

Event : ESC Preventive Cardiology (Formerly EuroPrevent) 2015

  • Topic : preventive cardiology
  • Sub-topic : Risk Factors and Prevention
  • Session type : Poster Session

Authors : F Byazrova (Moscow,RU), V Buza (Moscow,RU), V Lopukhova (Moscow,RU), K Zykov (Moscow,RU), V Masenko (Moscow,RU), A Samko (Moscow,RU), YU Karpov (Moscow,RU)

Authors:
F Byazrova1 , V Buza1 , V Lopukhova1 , K Zykov1 , V Masenko1 , A Samko1 , YU Karpov1 , 1Russian Cardiology Research and Production Complex - Moscow - Russian Federation ,

Citation:

Background. Atherosclerosis is a chronic inflammatory disease and it is important to study  various inflammatory markers as possible predictors of atherosclerosis. In particular, the evaluation of the eosinophils' activity, determined by the level of eosinophil cationic protein (ECP). Purpose. To compare the level of eosinophil cationic protein  in patients with different degrees of severity of coronary atherosclerosis. Methods. The study included 168 patients (119 males) aged from 54 to 67 years (mean age 60 years), undergoing coronary angiography. The ECP level in all the patients had been measured before the procedure. Results. According to the results of the coronary angiography, the patients were divided into several groups: the patients with normal coronary arteries (NCA) (n=17); the patients with primary coronary  atherosclerosis (n=11); the low (n=109), intermediate (n=16) and high (n=11) risk patients according to the Syntax scale. The ECP level in the patients with NCA  was significantly lower than the groups of middle and high risk according to the Syntax scale and amounted to 8.7 ng / ml (6.5 ng / ml - 11.5 ng / ml), 11.9 ng / ml (11.2 ng / ml - 15.9 ng / ml) and 15.6 ng / ml (8.9 ng / ml -18.8 ng / ml) respectively (p <0.05).Conclusion. In the groups with severe coronary atherosclerosis (the groups of medium and high risk according to the Syntax scale) ECP rate was significantly higher than in patients with NCA, suggesting increasing activity of eosinophils during the progression of coronary atherosclerosis.

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