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Carotid intima media thickness in patients with cardiac syndrome X and its association with impairment of coronary angiography indexes
Authors : V Sucato (Palermo,IT), E Corrado (Palermo,IT), S Evola (Palermo,IT), A Sansone (Palermo,IT), G Novo (Palermo,IT), G Coppola (Palermo,IT), G Andolina (Palermo,IT), P Assennato (Palermo,IT), S Novo (Palermo,IT)
1University Hospital Paolo Giaccone, Biomedical Department of Internal Medicine (DiBiMIS) - Palermo - Italy
Purpose: The aim of this study was to evaluate in patients with cardiac syndrome X (CSX) the relationship between microvascular dysfunction and increase of carotid intima media thickness (C-IMT) using validated angiography indices
Methods: Our study was performed on a population 124 patients with CSX that underwent coronary angiography and carotid ultrasound. We divided the sample into two categories: patients with increase of C-IMT and those without increase. We calculated, on angiographic images, validate angiography indexes like TIMI Frame Count (TFC) and Myocardial Blush Grade (MBG) on three major coronary arteries.
Results: Our sample compared two groups: patients with increase of C-IMT (n-63) and patients without increase of C-IMT (n-61). Analysis trough angiography indexes showed that patients with increase C-IMT had a longest TFC of three major coronary arteries (TFC LAD 44, 7 +/- 12, 5; TFC RCA 26, 2 ± 6.9; TFC CX 27 ± 5,9), than control group, index of a coronary flow slowed with good statistical result on left anterior descending artery (p value 0.02), circumflex coronary artery (p-value 0.05). So, we found lower MBG on three coronary arteries (MBG LAD 2,5 ± 0,3; MBG RCA 2,3 ± 0,3; MBG CX 2,1 ± 0,32) in patients with increase of C-IMT than control group, with good statistical significance on left anterior descending artery (p value 0.02), circumflex coronary artery (p-value 0.04).
Conclusion: Analysis of microcirculation trough angiography indexes in patients with CSX with increase of C-IMT and without has led to asses that patients with increase of C-IMT population has a greater involvement of microcirculation than patients without.
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