1I.M. Sechenov First Moscow State Medical University, clinic of the internal disease - Moscow - Russian Federation
Aim: to evaluate endothelial dysfunction and the level of serum marker of apoptosis (caspase-8) in patients with metabolic syndrome (MetS).
Methods: The study included 76 patients: 43 patients with MetS, 33 patients without MetS (control group), the average age of 61±12 years. Assessment of endothelial dysfunction was performed using the photoplethysmography; the level of caspase-8 was investigated.
Results: The duration of systole in the group with MetS (ED%) was significantly higher than in control (p=0,037). Occlusion index and phase shift in basic group was significantly lower (1,43±0.44 and -6,14±5,7) in comparison with the control (1,68±0,6 and -2,65±7,69) respectively, p<0,05. A negative correlation has been identified between the index of occlusion and arterial hypertension, diastolic dysfunction, left ventricular hypertrophy, presence of coronary artery disease,?<0,05. An average level of caspase-8 in a group with MetS was significantly higher than in control (p=0,022). Positive correlation was revealed between the level of caspase-8 on the one hand and obesity (r=0,229)*, atherosclerosis of aorta (r=0,310)*, liver steatosis (r=0,462)* and pancreatic steatosis (r=0,354)*, nonalcoholic steatohepatitis (r=0,309)* on the other hand, *p<0,05.
Conclusions: In patients with MetS compared with the control group the following have been identified:
1) Increased duration of systolic function that can indicate a diastole time reduction, the deterioration of myocardial perfusion;
2) A higher frequency endothelial dysfunction occurrence in large muscular and small resistant arteries;
3) A higher level of caspase-8;
All the above can serve as a risk factor and prognostic marker of adverse development of cardiovascular and hepatobiliary diseases.