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Inverse association between central obesity and arterial stiffness in Korean subjects with metabolic syndrome: a cross-sectional cohort study

Session Poster Session III - Friday 08:30 - 12:30

Speaker Assistant Professor Ki-Bum Won

Event : ESC Preventive Cardiology (Formerly EuroPrevent) 2015

  • Topic : preventive cardiology
  • Sub-topic : Obesity
  • Session type : Poster Session

Authors : K-B Won (Daegu,KR), H-J Chang (Seoul,KR), I-J Cho (Seoul,KR), C-Y Shim (Seoul,KR), G-R Hong (Seoul,KR), N Chung (Seoul,KR)

K-B Won1 , H-J Chang2 , I-J Cho2 , C-Y Shim2 , G-R Hong2 , N Chung2 , 1Keimyung University Hospital Dongsan Medical Center, Cardiology - Daegu - Korea, Republic of , 2Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Cardiology Division - Seoul - Korea, Republic of ,


Introduction: Metabolic syndrome (MetS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. Whether central obesity (CeO) is a prerequisite for the diagnosis of MetS in the International Diabetes Federation (IDF) definition is a substantial issue because it may influence the clinical value of MetS for predicting subclinical atherosclerosis.

Methods: We investigated the relation between MetS, as defined by the National Cholesterol Education Program–Adult Treatment Panel III criteria, and arterial stiffness measured using brachial-ankle pulse wave velocity (baPWV) according to CeO status in 2,560 healthy Korean subjects who participated in a community-based cohort study.

Results: The prevalence of MetS was 40%; 85% of MetS subjects had CeO. The prevalence of diabetes was higher in MetS subjects than in non-MetS subjects (30 vs. 8%, p<0.001). The number of MetS components (MetSN) was correlated with baPWV (r=0.311, p<0.001). In a subgroup analysis of MetS subjects, the prevalence of diabetes was not significantly different in MetS subjects with and without CeO. MetS subjects without CeO had higher baPWV than those with CeO (1654±315 vs. 1578±270 cm/s, p=0.002). Multiple regression models revealed that CeO was inversely associated with baPWV in MetS subjects.

Conclusion: Despite the significant correlation between MetSN and arterial stiffness, there appeared to be an inverse association between CeO and arterial stiffness in MetS subjects. In contrast to the IDF definition, CeO might not be crucial for the diagnosis of MetS in healthy Koreans having multiple metabolic risk factors with respect to subclinical atherosclerosis reflected in arterial stiffness.

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